Course Overview

This class will discuss various special topics at the interface of chemistry and biology.


1. Nucleic acid structure and synthesis

2. DNA sequencing and mimetics

3. RNA: RNA interference

4. Ribozymes and aptamers

5. Carbohydrates: structure

6. Carbohydrates: biosynthesis and function

7. Carbohydrates: applications

8. Carbohydrates: chemical synthesis

9. Introduction to lipids and membranes

10. Lipid structure

11. Protein synthesis and folding

12. Protein degradation and quality control

13. Protein misfolding and neurodegeneration

14. Producing proteins and peptides

15. Chromatography and electrophoresis

16. Protein extraction, subcellular fractionation, centrifugation

17. Antibody technologies

18. Humanized antibody

19. Structural Biology

20. Labeling with fluorophores and biotin

21. Fluorescent proteins and FRET

22. Basics of Fluorescence Microscopy

23. Super-resolution Optical Microscopy

24. Bioorthogonal chemistry; Active site probe

25. Mass spec: instrumentation

26. Mass spec of proteins

27. Mass spec and protein quantification

28. Post-translational modifications

Learning Achievement

Understand the chemical principles behind the materials and methods commonly encountered in modern biology labs. Apply chemical thinking to solve biological problems.

Competence

Course prerequisites

*Majors-only (including minor and double major students). *Restrict to graduate students.

Grading Philosophy

Course schedule

Course type

Online Course Requirement

Instructor

Hwan-Ching Tai

Other information

Division of Chemical Biology

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