Course Overview

This course covers the current knowledge on the molecular and cellular mechanisms involved in the control of hematopoiesis and hematopoietic defects that are etiologic in human hematologic disorders

Learning Achievement

Discussing the cell and molecular mechanisms of control of hematopoiesis, maintenance of pluripotency and hematopoietic stem cell differentiation. Discussing the mechanisms regulating hematopoiesis which are abnormal in hematological diseases, particularly in bone marrow failure and myeloid neoplasias.

Competence

Course prerequisites

Grading Philosophy

The discipline is held in a weekly basis and students’ evaluation will be based on: 1. Frequency and participation; 2. Seminars presentation; 3. Top

Course schedule

Lectures on (1) hematopoiesis and (2) bone marrow failure. Seminars on pluripotency, stemness, hematopoietic differentiation, cellular reprogramming; immunology of hematopoiesis, niche; DNA repair machinery, telomere biology, clonality in hematopoieses, malignant clonal evelution, epigenetics, and investigational tools: Southern blot, Westem blot, coimmunoprecipitation, qPCR, PCR-array, genetic sequencing, colony-forming assays; immunophenotyping

Course type

Online Course Requirement

Instructor

Rodrigo do Tocantins Calado de Saloma Rodrigues

Other information

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