Biochemistry IV – Biochemistry of Membrane Receptors Ruhr-Universität Bochum
In the context of the specific topics listed below, reference will be made to those basic concepts of previous lectures (Biochemistry I-III) that are considered crucial for an in-depth understanding of the principles of biochemistry. Contents: Cell-cell contacts; Cell-cell adhesion; Voltage-activated ion channels; Presynaptic function and vesicle release; Ligand-activated ion channels; Structure of the synapse; Signal transduction pathways; Receptor protein tyrosine kinases; Signal transduction of cellular survival; Phosphotyrosine phosphatases; Non-receptor ryrosine kinases; Cytokines; Seven-transmembrane receptors/G proteins (GPCRs)
Students will gain an overview of the various membrane receptors and ion channels, their structure-function relationships, and the intracellular signal transduction pathways these receptors are connected to. A further focus will be on understanding the interplay between different signal transduction pathways as well as the regulatory principles governing them. Students are supposed to grasp the wide-ranging implications that signal transduction pathways have for cell physiology and the organism as a whole. Furthermore, students are expected to learn and understand basic concepts in biochemistry.
Familiarity with the contents of the Bachelor studies course lectures Biochemistry 0, I, II, and III.
Passing the written end-of-term exam
Week1: Introduction Week2: followed by Week3 to the Final Week
Online Course Requirement
Michael Hollmann, Rolf Heumann
Every summer semester Note-taking during lectures is encouraged. Independent post-preparation of module contents as well as independent consultation of course material is recommended to prepare for the exam.
Site for Inquiry
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Email address: https://www.chemie.ruhr-uni-bochum.de/imperia/md/content/chemie/studium/modulhandbuch_ba_biochemie_05_2019.pdf#page=71