Factors Associated with Cancer Development in Young Patients University of Sao Paulo
Most studies in Oncology, including tumor molecular biology and therapeutic clinical trials, have focused on cancers that occur in children and older adults. Recently, the interest in characterizing cancers affecting young adults has increased. Estimates in our state indicate that 4.8-5.0% of cancer cases occur in young adults aged 20-34 years (http://www.fosp.saude.sp.gov.br/epidemiologia/dados_rhc.php). Between 2000 and 2009, the Cancer Hospital Registry Bulletin of the Oncocentro Foundation of S_o Paulo (RHC / FOSP Bulletin, 2011) reported 13,373 cancer cases in adolescents and young adults, 40% in males and 60% in females. In general, germline mutation carriers in cancer predisposing genes develop the disease at an early age, however, only 10-20% of young patients have mutations in these genes, and the development of cancer remains largely unexplained. Habits and environmental factors, which may be involved in the processes of genetic damage or epigenetic events that control gene expression, may also influence the development of cancer. This course intends to explore the role of gene mutations and environmental factors in the development of cancer in young patients
To investigate hereditary and environmental factors involved in the development of cancer in young adults, including family history, habits, gene mutations.
Presentation of seminars and / or written examination
Cancer in young adults and: 1. Germline mutations in cancer predisposing genes; 2. Environmental factors modifying the risk of cancer; 3. Gene polymorphisms; 4. Somatic mutations; 4. Prognosis
Online Course Requirement
Maria Aparecida Azevedo Koike Folgueira, Geertruida Hendrika de Bock
Site for Inquiry
Please inquire about the courses at the address below.
Email address: http://www.fm.usp.br/en/portal/