Course Overview

OBJECTIVES 
Knowledge and understanding of intra-tumoral heterogeneity and tumor
microenvironment elements at the origin of cancer initiation,
progression and dissemination: recent methods and pre-clinical
experimental models used, clinical implications and challenges for
treatment. Being able to design and implement experimental approaches,
models and methods to study microenvironment and tumor heterogeneity
in oncology translational research; to extract information from cancer
molecular databases; to critically analyze scientific news.

Learning Achievement

Competence

Course prerequisites

Grading Philosophy

Course schedule

- Intra-tumoral heterogeneity, hierarchical organization.
Interactions between cancer stem cells and their microenvironment
(stromal, vascular, immune, microbiota, niche). Clinical implications
and challenges for treatment. 
- Hematological cancers: stem cell heterogeneity and hierarchy in
hematological malignancy. Chronic myeloid leukemia. 
- Epithelial-Mesenchymal transition, invasion and metastasis.
RhoGTPases and invasion in hepatocellular carcinoma. Invadopodia in
Melanomas progression. 
- Gastrointestinal adenocarcinoma: characterization and targeting of
cancer stem cells in gastric carcinoma; cancer stem cells and
metastasis initiating cells in colorectal cancer 
- Tumor neo-angiogenesis : example in brain tumors (glioblastoma). 
- Metabolism and NADPH oxidases in skin cancer. 
- Immune and infectious microenvironment. H. pylori and gastric
cancer. Bacterial genotoxins and digestive cancers. CMV infection and
LTgd in colorectal cancer.

Course type

- Theoretical lectures - 3 hours  - Integrated classes - 44 hours  - Tutorial classes - 4 hours

Online Course Requirement

Instructor

Other information

Language of instruction: English

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