Course Overview

> This course is is divided in two courses CO1 (Organic Chemistry 1)
and CO2 (Organic Chemistry 2):

- CO1 is the first course in the three years undergraduate organic
chemistry lecture sequence CO1 to CO6. Students will learn the basic
principle to understand the structure and reactivity of organic
molecules (conformations, stereo chemistry, electronic effects,
resonance).
- CO2 is a continuation of CO1. Students will understand the
reactivity of aliphatic compounds (alkanes, alkenes, alkynes) and
aromatic compounds (benzene derivatives).

Learning Achievement

Competence

Course prerequisites

High-school diploma.

Grading Philosophy

> 3 written exams:

- Exam CO1 - 1h20, 20% weight of overall mark.
- Exam CO2 - 1h20, 20% weight of overall mark.
- Final exam CO1+CO2 - 1h30, 60% weight of overall mark.

> In case of failure, a second session is organzed for the final exam,
either as a written final exam or an oral session depending on the
number of failed students. This 2nd session takes place at the end of
June.

Course schedule

> CO1:
     -_Isomerism_,

- Lewis structures, molecular orbitals and covalent bonding,
conformations: ethane, propane, butane, cycloalkanes. Configurations:
optical activity, chirality, Fischer projections, absolute
configurations, the R/S notational system  of absolute configuration,
diastereomerism: relative configurations, the E/Z notational system of
alkenes.

       - _Electronic effects_

- Polar covalent bonds, Inductive effects. Multiple bonds, resonance
forms, contributing structures, mesomeric effects,
electron-withdrawing and electron-donating groups. Aromaticity:
benzene and benzenoid aromatic compounds, Hückel’s rule.

       - _Types of reactions and reagents_

- Types of reactions: substitution, addition, elimination,
rearrangement. Bond breaking and bond forming. Types of reagents:
electrophiles, nucleophiles, radicals. Acid-base reactions. Reaction
intermediates and their relative stabilities (carbocations,
carbanions, free radicals). Hammond postulate, potential-energy
diagrams, catalysis.

> CO2:
        - _Kinetic and thermodynamic of reactions_

- Equilibrium and energy profiles (equilibrium constant,
potential-energy diagrams, equilibrium constant and free energy).
Activation energy, kinetic equations, intermediate and transition
state, kinetic and thermodynamic control of reactions.

         - _Alkanes_

- Physical and chemical properties, conversion of petroleum:
pyrolysis (cracking reaction), radical halogenation: mechanism,
selectivity, regioselectivity. Combustion.

         - _Alkenes, alkadienes, and alkynes_

- Physical and chemical properties, reaction mechanisms:
electrophilic and radical additions, catalytic hydration, addition and
rearrangement, halogenation, hydrogenation, hydroboration, oxidation,
electrophilic addition with conjugated dienes, Diels-Alder reaction.

         - _Arenes (benzene)_

- Electrophilic aromatic substitution reaction (EAS), mechanism of
EAS, intermediate in EAS reactions. Nitration, sulfonation,
halogenation, Friedel-Crafts alkylation and acylation, rate and
orientation in EAS reactions.

Course type

> Lectures are taught in French but all written supports are available in English: 20 x 1 hour and 20 minutes. > Practical sessions are taught in English: 20 x 1 hour and 20 minutes.

Online Course Requirement

Instructor

Other information

Duration: 14 weeks

Language of instruction: French and English * (See below: teaching methods)
Mode of delivery: Face-to-face teaching; E-learning

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