Organic Chemistry 1 and 2 University of Bordeaux
> This course is is divided in two courses CO1 (Organic Chemistry 1)and CO2 (Organic Chemistry 2): - CO1 is the first course in the three years undergraduate organicchemistry lecture sequence CO1 to CO6. Students will learn the basicprinciple to understand the structure and reactivity of organicmolecules (conformations, stereo chemistry, electronic effects,resonance). - CO2 is a continuation of CO1. Students will understand thereactivity of aliphatic compounds (alkanes, alkenes, alkynes) andaromatic compounds (benzene derivatives).
> 3 written exams: - Exam CO1 - 1h20, 20% weight of overall mark. - Exam CO2 - 1h20, 20% weight of overall mark. - Final exam CO1+CO2 - 1h30, 60% weight of overall mark.> In case of failure, a second session is organzed for the final exam,either as a written final exam or an oral session depending on thenumber of failed students. This 2nd session takes place at the end ofJune.
> CO1: -_Isomerism_, - Lewis structures, molecular orbitals and covalent bonding,conformations: ethane, propane, butane, cycloalkanes. Configurations:optical activity, chirality, Fischer projections, absoluteconfigurations, the R/S notational system of absolute configuration,diastereomerism: relative configurations, the E/Z notational system ofalkenes. - _Electronic effects_ - Polar covalent bonds, Inductive effects. Multiple bonds, resonanceforms, contributing structures, mesomeric effects,electron-withdrawing and electron-donating groups. Aromaticity:benzene and benzenoid aromatic compounds, Hückel’s rule. - _Types of reactions and reagents_ - Types of reactions: substitution, addition, elimination,rearrangement. Bond breaking and bond forming. Types of reagents:electrophiles, nucleophiles, radicals. Acid-base reactions. Reactionintermediates and their relative stabilities (carbocations,carbanions, free radicals). Hammond postulate, potential-energydiagrams, catalysis.> CO2: - _Kinetic and thermodynamic of reactions_ - Equilibrium and energy profiles (equilibrium constant,potential-energy diagrams, equilibrium constant and free energy).Activation energy, kinetic equations, intermediate and transitionstate, kinetic and thermodynamic control of reactions. - _Alkanes_ - Physical and chemical properties, conversion of petroleum:pyrolysis (cracking reaction), radical halogenation: mechanism,selectivity, regioselectivity. Combustion. - _Alkenes, alkadienes, and alkynes_ - Physical and chemical properties, reaction mechanisms:electrophilic and radical additions, catalytic hydration, addition andrearrangement, halogenation, hydrogenation, hydroboration, oxidation,electrophilic addition with conjugated dienes, Diels-Alder reaction. - _Arenes (benzene)_ - Electrophilic aromatic substitution reaction (EAS), mechanism ofEAS, intermediate in EAS reactions. Nitration, sulfonation,halogenation, Friedel-Crafts alkylation and acylation, rate andorientation in EAS reactions.
> Lectures are taught in French but all written supports are available in English: 20 x 1 hour and 20 minutes. > Practical sessions are taught in English: 20 x 1 hour and 20 minutes.
Online Course Requirement
Duration: 14 weeksLanguage of instruction: French and English * (See below: teaching methods)Mode of delivery: Face-to-face teaching; E-learning
Site for Inquiry
Please inquire about the courses at the address below.
Contact person: Denis Deffieuxdenis.firstname.lastname@example.orgSylvain Nlatesylvain.email@example.com