Biological sciences | Subject

Biology and Interdisciplinarity Biotechnologies: Issues and Strategies Cell Biology and Development Cell Physiology: Neuronal and hormonal communication General Ecology Genetics History of Science Bionorganic chemistry

This teaching module focuses on the main principles used in bioinorganic chemistry: i) to understand and mimic the metal binding sites naturally found in biological systems, and ii) to anticipate potential interactions of toxic metals or metal-based drugs in living organisms. A first part will be dedicated to the behavior of metal complexes in biologically-relevant conditions. We will present the main analytical and spectroscopic tools useful to decipher the nature of the metal complexes both in abiotic compounds and proteins. In a second part, important metal active sites (on the catalytic, therapeutic and biological points of view) will be described in details. The last part deals with the concept of bioinspired chemistry. We will see how bioinorganic chemists design complexes that are able to mimic natural systems. Chemistry and Biology Department (UFR Chimie et Biologie) Grenoble – Domaine universitaire IG3NNLC4 6 2nd year of master Lecture Course content can evolve at any time before the start of the course. It is strongly recommended to discuss with the course contact about the detailed program.

Please consider the following deadlines for inbound mobility to Grenoble:
– April 1st, 2020 for Full Year (September to June) and Fall Semester (September to January) intake ;
– September 1st, 2020 for Spring Semester intake (February – June). Agnès VERE
chimie-biologie-ri@univ-grenoble-alpes.fr

Epigenetics and cell differentiation

Course outline Today, the term “epigenetics” is used to describe the study of heritable changes in genome function that occur without a change in DNA sequence. This includes the way gene expression is passed from one cell to its progeny, how gene expression changes during the differentiation of one cell type into another, and how environmental factors can change the way genes are expressed. Epigenetic regulation involves changes of chromatin structure. Interestingly, the mechanisms involved in epigenetic regulation, such as histone modifications, also participate in the transient changes of gene expression. This course is therefore opened to all students with an interest in the control of gene expression. There are far-reaching implications of epigenetic research for plant and human biology and disease. The different mechanisms involved in epigenetic regulation, and the different contexts involving epigenetic regulation will be presented: – actors involved in epigenetic regulation (role of histone modification, chromatin remodeling complex, histone variants, DNA methylation, small and long noncoding RNA), – contexts involving an epigenetic regulation (response to cell environment, cell differentiation, development) – implication in diseases. Chemistry and Biology Department (UFR Chimie et Biologie) Grenoble – Domaine universitaire IG7OAVQT 6 2nd year of master Lecture Course content can evolve at any time before the start of the course. It is strongly recommended to discuss with the course contact about the detailed program.

Immunity against cancers and infectious diseases

Immune responses against cancers occur and erase most of the developing tumors. Unfortunately, some cancers escape the spontaneous immune responses we are mounting to become a clinical challenge. Lectures will be devoted to detail what is currently tested in tumor immunotherapy to control or cure developing tumors. A parallel with immunological responses against infectious agents will be made. Conferences will be given by researchers originating from Grenoble but also outside (Paris, Marseille, Lyon, and Dijon) to expose enrolled students to Immunology researches performed nationwide. All these researchers are susceptible to host Master 2 students during their internship. The particularity of this UE resides in the fact that some lectures are mutualized via videoconferences with the Master of Immunology from Paris V, VI, and VII. The mid-term evaluation will consist in the presentation of a selected conference by an individual student. Chemistry and Biology Department (UFR Chimie et Biologie) Grenoble – Domaine universitaire IG3KKSUC 6 2nd year of master Lecture Course content can evolve at any time before the start of the course. It is strongly recommended to discuss with the course contact about the detailed program.

Molecular genetics and epigenetics

This course concerns all the students interested in gene expression across the tree of life: bacteria, lower (yeast, protozoans) and higher eukaryotes (plants, mammalian). It is complementary to the M1 course “Cell Compartmentalization and Implications in Pathology”. You will gain further knowledge on the mechanisms involved in the control of gene expression in the general context of gene regulation. The course will present the new developments for the analysis and control of gene expression. This will include in vitro and in vivo approaches that can be usedin cells and living organisms. A specific emphasis will be given to new aspects of gene regulation at a transcriptional and post-transcriptional level (RNA maturation and transport). The role of epigenetic regulation involving DNA methylation, post-translational histone modification, long and short non-coding RNA and histone variants in the control of gene expression will also be addressed. The broad range of model organisms (human, mouse, plants, yeast, bacteria…) and questions addressed in this course makes it a “must take” for those interested in evolution, development, cell differentiation, senescence, infectious diseases and pathologies such as cancer. Therefore, this course is strongly recommended as a preparation to the PHED and NN Master 2 programs. Chemistry and Biology Department (UFR Chimie et Biologie) Grenoble – Domaine universitaire IG21YNQ0 6 1st year of master Lecture Course content can evolve at any time before the start of the course. It is strongly recommended to discuss with the course contact about the detailed program.

Neurophysiology

Full lectures on cognitive, sensory, limbic and motor systems from expert contributors, e.g.: – Neural basis of language – Brain’s rhythms: role and source – Neural basis of conscious and non-conscious processes Full lectures on physiopathology of non-degenerative diseases from MD and PhD contributors, e.g.: – Epilepsy physiopathology – Schizophrenia physiopathology – OCD: new pathophysiological insights – Drugs addiction and neuro-adaptation: hijacking of the reward system Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules. Targeted skills Chemistry and Biology Department (UFR Chimie et Biologie) Grenoble – Domaine universitaire IG3PVIOS 6 2nd year of master Lecture Course content can evolve at any time before the start of the course. It is strongly recommended to discuss with the course contact about the detailed program.