Developmental Biology is a convenional and facinating field of biology. It involves in the studies of embryonic and postembryonic development. sexual maturation, reproduction and aging. The revolution of technologies in molecular and celluar biology as well as microscopy has greatly accelerate the research in the field. Thus, the students in this course will be asked to read , dissect and present the most recent published papers in the field. To train student to read and present developmental biology-related paper in English. College of Life Science Main Campus Students need to present a paper at least once a month Shyh Jye Lee 20 LS7011 (B21EM0380) 2 (College of Life Science) Institute of Life Science
*Registration eligibility: juniors and above. http://www.LifeScience.ntu.edu.tw/2014c/

Each week, a faculty member or a student presents a discussion of one or a few related articles in the assigned topics. The article(s) should be deal with research in immunology and inflammation. College of Life Science Main Campus 1. Contact the course coordinator to enroll in the class. 2. All participants present at least twice. 3. Review the assigned articles before attending the class. 4. Participate in and contribute to class discussions. Hao-Sen Chiang 15 Wednesday 5,6 LS7032 (B21EM0500) 2 (College of Life Science) Institute of Life Science
http://www.LifeScience.ntu.edu.tw/2014c/

Based on the weekly subject listed in the syllabus, the lecturer and one participating student select a relevant review and a research article, respectively, for oral presentation followed by group discussion. The article(s) should relate to adaptive evolution or its application. College of Life Science Main Campus 1. Contact the course coordinator to enroll in the class. 2. All participants present at least twice. 3. Review the assigned articles before attending the class. 4. Participate in and contribute to discussion. Hsin-Hung Chou 15 LS7034 (B21EM0510) 2 (College of Life Science) Institute of Life Science http://www.LifeScience.ntu.edu.tw/2014c/

We will discuss the keys to be a successful scientist. Students are require to go through readings and write a summary before each discussion section. The aim for this course is to share good guidance of research activities with graduate students. College of Life Science Main Campus Everyone should finish the required readings before each discussion section. Actively participating during discussion is expected. David Zeleny 10 EEB7002 (B44EM0030) 1 (College of Life Science) Institute of Ecology and Evolutionary Biology http://ecology.LifeScience.ntu.edu.tw/english/index.htm

This is a compulsory course for first year graduate students. This course will focus on formulating dissertation proposals, generating bibliographies, conducting preliminary research, reviewing and creating a dissertation outline. It will also equip students with the skills required to seek out appropriate conferences and submit their technical reports to the journals specialized in applied and food microbiology. To assure students in the long-term process of research, writing and revise for their dissertation, and, meanwhile, to provide them the opportunity of generating a polished journal article in their graduating year. College of Bio-Resources & Agriculture Main Campus Cheng, Kuan-Chen 10 Wednesday 1,2 Biot7012 (642EM0130) 2 (College of Bioresources and Agriculture) Institute of Biotechnology
http://www.iob.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

Around half of the classes for this semester would be lecture based, while the other half will be in journal club format as well as “Author-reviewer role playing format”. We will select the most updated literature with significant breakthroughs in different layers of epigenomic regulatory machineries. These includes the studies on how DNA methylation, chromatin modification and remodeling, functional non-coding RNA machineries that coordinately regulate epigenetic landscape and this gene expression pattern and cell fate. We will also discuss wet bench experimental design and bioinformatic analytical tools for analyzing and consolidating DNA methylome, transcriptome, small RNA analysis, lincRNA and native elongating RNA-seq and Chromatin-ImmunoPrecipitation (ChIP)-seq, ChIRP (Chromatin Isolation by RNA purification) and RNA-IP-seq datasets. Contents of most recent international conferences, sometimes including unpublished data, will also be discussed. We will also periodically invite local and international experts to join our course. One week before their seminar, we will discuss their published research article to help students prepared for the actual interaction with world experts in the field. Students will be able to acquire the most up to date information in the developing Epigenomics field. Through discussing and critically evaluating most recent publications and international conference presentations, the students will also establish the ability to judge original research work and argue their points with scientific evidences. College of Bio-Resources & Agriculture Main Campus Already taken one of the following topics (or similar ones to be judged by the instructor): Epigenetics, Frontiers in Epigenetic regulatory mechanisms, Epigenetics in germ cells and stem cells, Cellular reprogramming, Frontiers in functional non-coding RNAs or Epigenomics. 10 Friday 6,7 Biot7014 (642EM0150) 2 (College of Bioresources and Agriculture) Institute of Biotechnology *Registration eligibility: graduate students. http://www.iob.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

This course will focus on mouse animal model to provide students a state-of-the- art of the technologies in embryo development and pluripotent stem cells (i.e. embryonic stem cells) research and its applications. The course will provide valuable opportunities for students to participate various practical training and knowledge in oocyte and embryo handling, in vitro fertilization, cryopreservation of egg and embryo, micromanipulation techniques (i.e. intracytoplasmic sperm injection and somatic cell nuclear transfer, embryo biopsy, blastocyst injection…etc), derivation and in vitro/in vivo characterizations of pluripotent stem cells. Understand the early embryo development and modern reproductive biotechnologies College of Bio-Resources & Agriculture Main Campus 5 Wednesday 2,3,4 Biot7022 (642EM0230) 3 (College of Bioresources and Agriculture) Institute of Biotechnology *Registration eligibility: graduate students. http://www.iob.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

Depends on the background of the students, 1/2 to 2/3 of the lectures will be given by the instructor for introducing basic concepts in Gametogenesis, Stem cells and the regulation by Genetics and Epigenetics. For the rest of the classes, students will be assigned the most updated original research papers as well as the milestone publications. They will be randomly divided into 2 groups for each assignment. One group will be presenting the articles and students in the other group are expected to challenge the papers from the experimental design, the methodology to the interpretation of the data. Students in the 1st group should defend for the papers as if it’s their manuscript. Students from the 2nd group should also provide constructive advice as how to improve the manuscript so that it can be published in a higher impact journal. On top of learning the basic concepts of gametogenesis, epigenetics and reprogramming, students are expected to develop the ability to critically evaluate and interpret published research articles. In addition, they will learn the art of reviewing as well as defending a manuscript for publication. College of Bio-Resources & Agriculture Main Campus Preferably having backgrounds in one of the following subjects: Biochemistry, Cell Biology, Genetics, Molecular Biology or Epigenetics 10 Thursday 3,4 Biot5005 (642EU0070) 2 *Registration eligibility: juniors and above.
(College of Bioresources and Agriculture) Institute of Biotechnology,
(College of Life Science) Geno and System Biology Degree Program
http://www.iob.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

This is a course in experimental design and data analysis. Computer simulations will be used to understand the concepts of various statistical tests, but no prior experience in programming is required. The experimental design part of the course will use a textbook (see below). The main theme of the data analysis part of the course is the maximum likelihood method although other approaches are also discussed. The computer language R (http://www.r-project.org/) will be used. Expectations