The measurement and quantification of population health could assist health policy making and priority setting. In the past few years there have been major advancements in burden of disease research, mainly led and stimulated by the Global Burden of Disease Study (GBD). This course will give an overview on the concepts and methods used to quantify the burden of disease at the national and global level. The GBD will be a main focus of this course, but other alternative approaches will also be reviewed. The course consists of lectures, computer labs, a hands-on group-based project, and a field visit to the Department of Statistics of Ministry of Health and Welfare. At the end of the course the students are expected to: 1. Understand the key concepts and elements in burden of disease studies 2. Comment on the strengths and limitations of burden of disease studies 3. Understand the estimating procedures of the GBD study 4. Be familiar with and be able to use the major databases of GBD while acknowledging their limitations College of Public Health Downtown Campus-College of Public Health The course will be offered in English. Basic understanding of key concepts of epidemiology will be helpful but is not absolutely required. Lin Hsien-Ho 30 Tuesday 6,7 EPM5018 (849EU0460) 2 (College of Public Health) Graduate Institute of Epidemiology and Preventive Medicine http://epm.ntu.edu.tw/?locale=en

This course is designed to provide students with a basic understanding of how health communication can be used in the field of health promotion, including strategic planning for integrated mass media campaigns and the development of health communication messages that are consonant with principles of behavioral sciences. This course reviews the role of health communication as a means of promoting public health and also stimulates thinking about how the power of health communication can be harnessed to advance a public health agenda. After completing this course, students will be able to: 1. Describe the history of health communication and underpinning theories 2. Understand the key elements of developing evidence-based health communication strategies 3. Describe all major steps involved in the health communication process other Downtown Campus-College of Public Health Assigned readings; attendance and participation; class discussions; concept papers; oral presentations Jiun-Hau Huang 30 Monday 3,4 HBCS7008 (850EM0090) 2 *Registration eligibility: graduate students.
(College of Public Health) Institute of Health Behaviors and Community Sciences http://hbcs.ntu.edu.tw/?locale=en

This Contemporary Issues in Global Health is designed for doctoral students, majoring in global health. This course will provide students with knowledge of cross-cutting global health theme and global burden of diseases, and ways of working together to improve global health. In addition to lecture, it will cover global health cases in Asia an Africa. College of Public Health Downtown Campus-College of Public Health 1. Preview each week’s reading material 2. Participation in class and at group discussions 3. Complete group assignments by the end of each class 4. Final project and presentation Chang-Chuan Chan 12 Friday 2,3,4 OMIH5125 (841EU5770) 3 (College of Public Health) Graduate Institute of Occupational Medicine and Industrial Hygiene http://omih.ntu.edu.tw/?locale=en

Introduce the core knowledge in environmental and occupational health. Understand the real-world application and practical issues through site visits. (The site visits may be arranged outside regular class time.) Be familiar with environmental factors affecting human health. Can summarize and interpret variables and indicators commonly used in the field of environmental and occupational health. College of Public Health Downtown Campus-College of Public Health Required course for students in the Global Health program of College of Public Health. Restriction: Doctoral and master students not in College of Public Health but with background in natural sciences may take this course. Please consult with the instructor first. This course is offered in English. Chang-Fu Wu 10 Tuesday 2,3,4 OMIH5126 (841EU5780) 3 (College of Public Health) Graduate Institute of Occupational Medicine and Industrial Hygiene http://omih.ntu.edu.tw/?locale=en

This is an elective course for students interested in toxicogenomics. Application of genomic technologies, i.e. genomics, transcriptomics, proteomics, and metabolomics will be introduced. Genomic technologies will be first discussed. The course will then focus on application of genomic approaches to study the adverse effects of environmental stressors on health of human and environment at gene, protein, and metabolite level. The class is offered in English. To learn the technologies in toxicogenomics and be able to apply techniques to conduct toxicological studies. College of Public Health Downtown Campus-College of Public Health There will be a mid-term and a final examination. An oral presentation is also required. The class is offered in English. Ching-Yu Lin 12 Monday 3,4 EH5018 (844EU1260) 2 (College of Public Health) Graduate Institute of Environmental Health
*Registration eligibility: juniors and above. http://ieh.ntu.edu.tw/?locale=en

Hazardous exposures are usually complex extended temporal processes leading to the development of biological responses, “damage/adverse responses/health effects”. A study intended to determine the quantitative relationship between exposure and risk of the effect requires a careful matching of the temporal variation in exposure with the kinetics of uptake, distribution and metabolism and matching those to the dynamics of response. However, bias and attenuation of the health risk estimate can be introduced when there is exposure error in air pollution measurement. Adequate exposure metrics may provide a means of reducing error (leading to less bias and uncertainty in health risk estimates) if they capture variability in exposure, which depends on the study design, health outcome, and pollutant of interest. To enable this, the course will start from a review of the basic components of exposure assessment for air pollution and subsequently introduce exposure metrics for four types of health outcomes: different combination of reversible/irreversible and discrete/proportional outcomes. Students will develop knowledge of exposure determinants and its temporal behavior (variability), in conjunction with skills for modeling temporal behavior of exposures and outcomes through simulations using excel spreadsheets. Guided critical analysis of publications will be performed, and information from simulations will be used to design an exposure assessment matched to the biology of the adverse effect(s). In the finals, the class will culminate with a design project where small groups of students design a new study of a specific exposure and hypothesized effect(s) reported in a previously critiqued scientific paper. The overall goal of this class is to develop the student’s ability to perform a biologically-based exposure assessment suited for testing an agent based hypothesis about a causal exposure-risk relationship in an epidemiological study. The specific learning objectives are: 1. The student’s knowledge base of exposure characteristics and assessment methods, and their application will be broadened through presentations, readings, critiques, and discussions of exposure assessment for environmental and occupational epidemiology. 2. The students will be introduced to a temporal modeling approach for simulating environmental and occupational exposures (exposure metrics), formulating a model of a linked exposure and health effects process as the basis for designing an epidemiologic study, and they will apply this approach to four different types of disease outcomes. 3. The students will be able to apply the knowledge and use their analytical skills to critique the exposure assessments and linkage with the health outcomes in selected publications. 4. Given a previously critiqued publication with a limited exposure assessment, the students will develop an improved study design using the temporal model approach that will provide a better test of the epidemiologic exposure-risk hypothesis, and present that approach to the class. College of Public Health Downtown Campus-College of Public Health The course sessions will include presentation on the topic of the day by the lecturer, and discussions of reading, review of homeworks, paper critiques, and other topics of interest. Wan-Chen Lee 12 Wednesday 6,7 EH5026 (844EU1360) 2 *Registration eligibility: juniors and above.
(College of Public Health) Graduate Institute of Environmental Health http://ieh.ntu.edu.tw/?locale=en

Introduction—Regenerative medicine New advances and applications in stem cell therapy Tissue engineering: the science and the technology Clinical applications of adult stem cells Materials for tissue engineering Nanotechnology for tissue engineering Hepatocyte transplantation Cell therapy for diabetes Stem cell therapy in neurodegenerative diseases Regenerative medicine in orthopedic diseases Regenerative medicine in cardiac diseases Regenerative medicine in dental diseases Regenerative medicine in dermatological diseases This course will introduce basic concepts, potential, techniques, and progress in currently developing “Regenerative Medicine”. Students will learn to interpret and evaluate published articles or presentations and gain a great vision on current trends of investigations in this field to lead their own research. College of Bio-Resources & Agriculture Main Campus Lee, Hsuan-Shu 20 Thursday 3,4 Biot7002 (642EM0030) 2 Non-degree Program: Teaching Programme of Stem Cell and Regenerative Bio-Medicine,
(College of Bioresources and Agriculture) Institute of Biotechnology,
(College of Bioresources and Agriculture) Institute of Biotechnology
*Registration eligibility: graduate students. http://www.iob.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

Nano/micro engineering technology has increasing impacts in biomedical research. The manipulation and measurement of this scale, ie,several hundred nanometers down to atomic resolution, is closely related to the dimension of many important biomolecules and the sampling of the volume down to this size has significant biomedical implications.The full understanding of a biological system is the first step of being able to control or even manipulate it in the future. In this course, we will introduce some basic nano/micro engineering techniques used at our lab for the biosensing, analysis, and manipulation at molecular, cellular and tissue levels. In previous years, the course is undergone by a weekly class with half part in literature discussion and the other half for technique introduction. In this year, we have made some changes by decreasing the literature discussion with most literature discussion dedicated on the identification of a biomedical issue; on the other hand, the related nano/micro techniques are introduced in more details and accompanied by approperiate demonstration. The choice of a term project has been changed from technique-based to biomedical issue-oriented.Instead of picking a technique and finding a biomedical application, the students have to identify a central question in biomedical research or come up with a device design to facilitate biomedical test, and then find the appropriate techniques to answer or fullfil the purpose and intention raised in their project. This will help students to pick up all the nano/micro engineering techniques which meet the biomedical research requirement. And with the guidance of the need in biomedical research, students will be able to foresee the future direction of technology advancement in assisting the biomedical research and practice. 1. Encourage the interdisiplinary discussion and enlarge the understanding of the core biomedical issues from a multidisciplinary view. 2. Gaining in-depth experience from a hands-on project. College of Engineering Main Campus In this semester, we will work on the theme of “Digital Nano Array” with microlabs on nanofabrication, measurement, and analysis. The students will be set into 2 groups for a hands-on term project. The students can pick an issue in biomedical research or practice. The focus given at this semester is “pre-processing of raw sample for subsequent biomolecule sensing.” The students need to specify their purpose and research methods and give an oral presentation on April 12. The complete experimental results will be delievered at the final report, which is on Jun 12, along with a paper report detailing the procedures and results. Chii-Wann Lin 10 Friday A,B,C Biomed7038 (548EM0650) 3 (College of Engineering) Graduate Institute of Bomedical Engineering,
Non-degree Program: Nano-Technology Engineering,
(College of Electrical Engineering and Computer Science) Graduate Institute of Biomedical Electronics and Bioinfornatics http://bme.ntu.edu.tw/english/

Students participate in the class will prepare case presentation from his/own patient pool. Each resident is assigned his / her own patients in the first year of the training program, most of which are expected to be completed by the end of the third year. Some of the unfinished cases will be transferred to the second year trainee from the graduates. The second year trainee will select a case undergoing treatment but treatment goal and efficiency not meeting the expectation. The third year trainee will select a completed case to review the treatment outcome. The presentation will begin with pre-treatment records, evaluating etiology, diagnosis, treatment planning, and treatment outcome (mid-treatment records or final records). Students are taught the important skills of cephalometric superimposition in order to differentiate the natural growth and treatment effects. After each case presentation, questions will be raised and fully discussed. All the presentation and discussion will be held in English. Problems in diagnosis, treatment planning, treatment procedures, treatment mechanics and management will be carefully reviewed based on individual cases. Constructive opinions will be given on improving treatment efficiency, treatment outcome or biomechanics. In this class, students learn how to a. obtain and create long term files of quality images of patients using techniques of photography, radiology and cephalometrics. b. collect and organize detailed treatment records which may include care from other providers. c. develop a foundation for understanding and planning treatment and implementation of appropriate treatment objectives and mechanics. d. evaluate treatment progress via cephalometric superimposition. e. manage and motivate patients to participate fully with orthodontic treatment procedures. Goal: for developing the skill of case presentation in English, evaluating the treatment result via cephalometric superimposition, exercising problem resolving ability in clinical setting College of Medicine Clinical Orthodontic Practice (Ⅰ), Clinical Orthodontic Practice (Ⅱ) Chung-Chen Yao 30 Monday 6 CDent7017 (422EM1120) 1 (College of Medicine) Graduate Institute of Clinical Dentistry http://gicd.ntu.edu.tw/main.php?Page=N1

Students participate in the class will prepare case presentation from his/own patient pool. Each resident is assigned his / her own patients in the first year of the training program, most of which are expected to be completed by the end of the third year. Some of the unfinished cases will be transferred to the second year trainee from the graduates. The second year trainee will select a case undergoing treatment but treatment goal and efficiency not meeting the expectation. The third year trainee will select a completed case to review the treatment outcome. The presentation will begin with pre-treatment records, evaluating etiology, diagnosis, treatment planning, and treatment outcome (mid-treatment records or final records). Students are taught the important skills of cephalometric superimposition in order to differentiate the natural growth and treatment effects. After each case presentation, questions will be raised and fully discussed. All the presentation and discussion will be held in English. Problems in diagnosis, treatment planning, treatment procedures, treatment mechanics and management will be carefully reviewed based on individual cases. Constructive opinions will be given on improving treatment efficiency, treatment outcome or biomechanics. In this class, students learn how to a. obtain and create long term files of quality images of patients using techniques of photography, radiology and cephalometrics. b. collect and organize detailed treatment records which may include care from other providers. c. develop a foundation for understanding and planning treatment and implementation of appropriate treatment objectives and mechanics. d. evaluate treatment progress via cephalometric superimposition. e. manage and motivate patients to participate fully with orthodontic treatment procedures. Goal: for developing the skill of case presentation in English, evaluating the treatment result via cephalometric superimposition, exercising problem resolving ability in clinical setting College of Medicine Review of Orthodontic Treatment Results (Ⅱ) Chung-Chen Yao 30 Monday 6 CDent7019 (422EM1140) 1 (College of Medicine) Graduate Institute of Clinical Dentistry http://gicd.ntu.edu.tw/main.php?Page=N1