Embryology is an old but fascinating subject. From the morphological

observation of chick embryo development to the unravel of the molecular

control of embryonic development in a variety of organisms, we have gone a

long way. However, the more we learn the less we know. It is a miracle to see

how a single cell develop into a fully functional adult. This course is design

to build the ground for students with interest in embryology. We will discuss

the basic principles and molecular controls of embryonic development. In

particular, we will emphasize the progression from immature gametes,

fertilization, cleavage to gastrulation (i.e. the formation of gut). The cell

fate and embryonic axis formation will also be included. The popular

experimental models used by current developmental biologist will also be

examined in detail.

1. Learn the developmental processes, regulatory mechanisms during embryogenesis.

2. Expose to developmental biology research by paper discussion

3. Stimulate scientific thinking by fomulating a proposal

College of Life Science Main Campus *Restrict to 3rd-year and above. Shyh Jye Lee 15 Monday 3,4 LS5019 2 Half Department of Lifescience, Institute of Lifescience, Teaching Programme of Stem Cell and Regenerative Bio-Medicine http://www.lis.ntu.edu.tw/en

This course intends to introduce the basic neuroscience. The course is designed for students without Neuroscience background, or even without Biology background. The scope of the course covers the basic structure and sensory and motor function of the nervous system, as well as the high function of the brain and related diseases. Students are expected to gain a broad perspective of how neural information is processed in the brain, and how brain activity determines individual behaviors in response to environmental stress. College of Life Science Academia Sinica Chen Chi Cheng 20 Wednesday 6,7,8 TIPGIN8003 3 Half Taiwan International Graduate Program In Interdisciplinary Neuroscience http://ecology.lifescience.ntu.edu.tw/english/index.htm

This course focuses on establishing epidemiologic concept and the ability of research design, and performing data analyses for observational studies. This course includes three parts: The first part is study design, which gives an introduction of causal inference and the principle of study design. The second part is analytical method, which gives an introduction on data analyses and the applications of statistical method. The third part is critical appraisal, which establishes students ability in reviewing specified literatures. The content of this course mainly follows the book Rothman KJ. Epidemiology: An Introduction. New York: Oxford University Press (2002) with the addition of chapters from other reference books. The examples from Taiwan unique research topics are given and illustrated in the course. For the latter part of this course, students will receive three papers for critical review and then present the results.

For lab data analysis, some example datasets will be distributed to students. Each week, students perform statistical analyses using these datasets and then send TA homework a week later. TA will demonstrate the SAS code and provide the answers for specific topics.

Students may use SAS, Stata, SPSS, and R programs for preparation the homework and lab data analyses.
This course establishes the following competencies via (1) the introduction of epidemiologic concept and research design using Taiwan unique research topics, (2) practice of data analysis, and (3) training on critical review:

1. Correctly use the principle of causal inference on literature reading and doing doctoral research.

2. Understand how random variation and bias affect research findings.

3. Understand the principle of cohort study and case-control study.

4. Learn Taiwan unique research topics.

5. Use statistical program to analyze example data set for observational studies.

College of Public Health Downtown Campus – College of Public Health Lin Hsien-Ho 20 Wednesday 6,7,8 EPM8002 3 Half Graduate Institute of Epidemiology and Preventive Medicine http://epm.ntu.edu.tw/?locale=en

The use of light for scientific investigation in biomedical research and non-invasive diagnostics has become increasingly important and popular thanks to high sensitivity, minimum perturbation to living organisms, functionality and affordable cost of optical instruments enabled by recent advances in both photonic and electronic technologies. This course is designed to cover the principles, concepts, practical implementations and applications of optical spectroscopy and imaging techniques that are commonly used for biomedical sensing and diagnosis. The first part of the course introduces absorption, fluorescence, infrared, elastic scattering and Raman scattering spectroscopies. The second part of the course introduces various optical imaging techniques including conventional light microscopy techniques (phase contrast, darkfield, polarization, differential interference contrast, structured illumination), confocal microscopy, optical coherence tomography, multiphoton microscopy, quantitative phase microscopy and super-resolution imaging. Recent applications of various optical techniques in medical diagnostics will also be reviewed. The objective is to provide the students with a working knowledge of these techniques with extended goals of enabling the students to choose appropriate tools for related biomedical research and preparing the students for further development of instruments and applications. College of Electrical Engineering & Computer Science Main Campus Sung Kung-Bin 20 Thursday 2,3,4 EE5132 3 Half Graduate Institute of Electrical Engineering,

Graduate Institute of Biomedical Electronics and Bioinfornatics http://www.ee.ntu.edu.tw/en/

Global Health Live Pacific is a graduate seminar for PhD and Masters graduate students. The seminar is held once per week for ten (10) weeks via live video (eg www.zoom.us) with international guest lecturers.

The course extends the theory of global health to the practice of global health. The relationship of health, foreign policy, and global health leadership are the cutting edge of the scope of the course. 1. Discuss key issues of current global health from an application perspective.

2. Expand networking opportunities for future global health career opportunities.

3. Practice and hone presentation skills and participate in case studies.

4. Construct a Mission, Vision, and Values (Personal) Career Statement.

5. List and describe global health leader’s characteristics.

College of Public Health Downtown Campus – College of Medicine_ *Restrict to graduate students and Ph.D. students. Chang-Chuan Chan 20 Tuesday 2,3,4 MPH7008 2 Half Master of Public Health, National Taiwan University Distance Learning http://mph.ntu.edu.tw/?locale=en

Many pieces of a puzzle have to be assembled to enable the successful translation of a novel idea into the clinic for the benefit of patients. First, the idea needs to be tested in a research environment before protecting and communicating the results, for example in a patent and/or journal publication. At this stage, the research can attract the interest of clinicians and/or manufacturers, who can help to progress the testing through clinical trials before a product can be launched. This course will give an overview over some of the main pieces of the puzzle that play a role on the path from the “bench to the bedside”, and will equip students with first-hand, up-to-date knowledge regarding aspects such as the management of intellectual property, regulatory requirements and standards, clinical trials and strategies for effective communication in an interdisciplinary environment. Furthermore, the students will be taken through several examples of successfully translated biomedical products to highlight key issues and pitfalls. Students gain a much sought-after understanding of the issues that are important for the successful translation of biomaterials research into the industrial world. College of Social Engineering Main Campus *Restrict to graduate students. Wei Bor Tsai 20 Monday 5,6,7 ChemE7039 3 Half Graduate Institute of Chemical Engineering http://www.che.ntu.edu.tw/che/?lang=en

The development of molecular biology revolutionized the way investigators conduct research. Techniques such as polymerase chain reaction, sequencing, gene knockdown and others became routine tools for researchers on molecular biology field. However, researchers from other areas may be not familiarized with such techniques. Considering the importance these techniques for science development is mandatory that the students from the graduate program in Anatomy have a minimal knowledge on molecular biology, allowing them to interpret publications with molecular data and to consider multiple approaches while developing their own research projects. Provide to graduate students: theoretical and practical concepts on molecular biology techniques, with emphasis on mammalian development applications; knowledge to interpret the results generated by molecular biology assays; a critical view of molecular biology techniques that can be used in scientific investigation, development of the necessary skills to use molecular biology and to critically analyze publications with molecular data. School of Veterinary Medicine and Animal Science (FMVZ) São Paulo main campus Essentials of molecular biology, nucleic acids extraction, polymerase chain reaction, restriction fragment length polymorphism, nucleic acid sequencing, real time PCR, high resolution melting, microarrays, genotyping, western blot, transgenesis and gene silencing. 25 VPS5745 4 Students will be assessed through participation in classes and the presentation of papers. http://ccint.fmvz.usp.br/index.php/en/

This course has the objective of teaching postgraduate students to become more effective writers, using practical examples and exercises. Topics include: principles of good writing, tricks for writing faster and with less anxiety, the format of a scientific manuscript, authorship, plagiarism. At the end, the students should delivery a short paper for peer review. This step is essential for the final evaluation. To learn about how to write an effective manuscript during the postgraduate course can help the students to report adequately your scientific results. Additionally, the program and the mentors could be benefited. Ribeir_o Preto Medical School (FMRP) Ribeirão Preto campus – Scientific project approved by Ethical Committee – Data explored/analyzed (at least partially) – Fluency in English – Personal computer (notebook) – operacional systems Linus, OS, Windows – Softwares installed: text editor (suggestion: Word_ or Pages_), reference manager (suggestion: Endnote_). – Introduction, the importance of a good writing divulgation – Good relationship with a text editor – Principles of effective writing – Crafting better sentences and paragraphs – Organization; and streamlining the writing process – The format of an original manuscript – Reviews, commentaries, and opinion pieces; and the publication process – Issues in scientific writing (plagiarism, authorship, ghostwriting, reproducible research) – How to do a peer review Om_ro Benedicto Poli N_tto 25 RGO5865 6 How much of a time commitment will this course be? – You should expect this course to require 4 to 8 hours of work per week. Any additional textbooks/software required? – There is no textbook for this course. PRESENCE: 91-100%: excellent, grade A; 81-90%: above average, grade B 71-80%: satisfactory, grade C; below 70%: unsatisfactory, grade D TASKS DELIVERED ON TIME*: All of them (5/5): excellent, grade A; 80% (4/5): above average, grade B 60% (3/5): satisfactory, grade C; below 40% (2/5): unsatisfactory, grade D * Tasks will be accepted only until to one week after. * If any task is not sent at this time (one week after), the grade will be decreased by “D” level. * Presence and tasks delivered on time will be compound as “Participation”: A+A=A; A+B=A; B+A=A;B+B=B; B+C=B; C+B=B; C+C=C; C+D=D; D+C=D; D+D=D. If D, the student will not be automatically reproved in the course. FINAL REPORT: graded from zero to ten by average grade among teacher and peer review (made by two colleagues). FINAL GRADE: It will be equal to �gFinal report�h x 100% if �gParticipation�h=A or 85% if �gParticipation”=B or 70% if �gParticipation�h=C. ATTENTION: Final grade will not be attributed if �gParticipation”=D. IMPORTANT: If any sign of plagiarism is detected, the student will have one additional week to sent a new version of the final work and will have the final grade decreased in 20%._ http://www.fmrp.usp.br/?lang=en

Currently, immunotherapy is an important therapeutic approach for the treatment of several diseases. In this context, this discipline is justified by addressing the current state and new perspectives of immunotherapies and advanced cellular therapies, making a connection between basic concepts and possible preclinical and clinical applications. Immunotherapy for cancer treatment is currently the most promising therapy in view of its selectivity, curative potential and low toxicity. This type of therapy has been described as the major scientific event of 2013 by the journal Science with emphasis on therapies with monoclonal antibodies (anti-CTLA-4 and anti-PD1) and genetically modified chimeric antigen receptor T cells (Chimeric Antigen Receptor T Cells, CAR T cells), which were able to induce potent antitumor response. In addition, this course enables interaction with professors and researchers from our and other research institutions, which develop works in this area of knowledge and present significant scientific and/or technological contribution in the field. The objective of this course is to introduce concepts about immunotherapies and cell therapies, as well as to discuss their application in the treatment of several types of diseases (hematological neoplasms, solid tumors, inflammatory diseases and immuno-mediated diseases.) In this context, immunotherapies already well established in the clinical context as well as innovative and advanced therapies using, for example, multipotent stem cells and genetically modified T cells. In addition, biotechnological advances in the areas of immunotherapy and cell therapy will be addressed. Ribeir_o Preto Medical School (FMRP) Ribeirão Preto campus The course will be taught through lectures, seminar presentation and discussion of articles. It will cover the following topics: 1. Immunotherapy, cell therapy, gene therapy: concepts and definitions. 2. Cellular immunotherapy (eg, NK cells, genetically modified T cells, dendritic cells, regulatory T cells, among others). 3. Immunotherapeutics (eg monoclonal antibodies, soluble receptors, receptor antagonists, purified total immunoglobulins, among others). 4. Immunotherapy: preclinical and clinical applications. 5. New biotechnologies in the area of immunotherapy (genetic modification, construction of chimeric antigen receptors, bioprocesses for cell expansion in bioreactors, humanized antibodies, among others). Maria Carolina de Oliveira Rodrigues,Kelen Cristina Ribeiro Malmegrim de Farias, Cristina Ribeiro de Barros Cardoso 25 RIM5754 4 There will also be the participation of invited researchers from this and other institutions every time the discipline is offered. 1) Didactic-scientific performance in seminars 2) Participation in discussions during lectures and seminars 3) Frequency http://www.fmrp.usp.br/?lang=en