The course aims to put the students in contact with researchers and professionals working in concentration areas of the Program (Clinical Chemistry, Physiopathology and Toxicology) and in related areas with the presentation of seminars on current advanced topics. The faculty includes national and international researchers. The course is offered in the first semester of each year and is mandatory for the all Doctorate students of the Program. This course will permit the students interact with different areas of research making it possible the acquisition of a broad and updated vision of Science in the concentration areas of the Program and in related areas. School of Pharmaceutical Sciences (FCF) S?o Paulo main campus The program will be determined every semester by the invited speakers. Topics will be preferentially include the areas covered by the Program (Clinical Chemistry, Physiopathology and Toxicology) but also related areas. Sabrina Epiphanio 60 FBC5792 1 Course will be taught in Portuguese and English. Participation in class, seminars report, and frequency. http://www.fcf.usp.br/english.php

The course aims to put the students in contact with researchers and professionals working in concentration areas of the Program (Clinical Chemistry, Physiopathology and Toxicology) and in related areas with the presentation of seminars on current advanced topics. The faculty includes national and international researchers. The course is offered in the first semester of each year and is mandatory for the Master and Direct Doctorate students of the Program. This course will permit the students interact with different areas of research making it possible the acquisition of a broad and updated vision of Science in the concentration areas of the Program and in related areas. School of Pharmaceutical Sciences (FCF) S?o Paulo main campus The program will be determined every semester by the invited speakers. Topics will preferentially include the areas covered by the Program (Clinical Chemistry, Physiopathology and Toxicology) but also related areas. Ana Paula de Melo Loureiro, Silvia Berlanga de Moraes Barros 60 FBC5793 1 Course will be taught in Portuguese and English. Participation in class, seminars report, and frequency. http://www.fcf.usp.br/english.php

Sterilization processes are performed in laboratories, hospitals and industries as the final processing step for preparation of safe critical materials and devices used in the Public Health sector and for pharmaceutical products, in order to preserve products and to ensure their expected shelf-life. A better understanding of sterilization processes (as the choice of sterilizing agent to be used, kinetic parameters determination and biological indicators application) can minimize misunderstandings related to contamination, production and/or processing of these pharmaceuticals devices. This course aims to present the basic concepts and parameters related to sterilization and validation processes, which are responsible to guarantee consistent sterility levels required for obtaining pharmaceutical and medical products. School of Pharmaceutical Sciences (FCF) São Paulo main campus 1. Introduction_- Concepts and application of sterilization. 2. Kinetic parameters: Decimal reduction time (D-value), Relative resistance (z-value), Sterility Assurance Level, Process equivalent time (F value), Q10 parameter and activation energy. 3. Biological and chemical Indicators: main characteristics, types, applications and relationship. 4. Sterilizing agents: Physical, chemical and gaseous agents. 5. Validation processes: definitions and legislation, qualification of installation, operating system qualification_and physical and biological validation. Practical: Application of biological indicators, determination of kinetic parameters Marina Ishii 13 FBT5736 6 Exercises and seminars. http://www.fcf.usp.br/english.php

The growing production of knowledge in the context of aseptic processing of health products and healthcare environment decontamination, such as biofilms, endotoxins, and prion proteins, among organic residue, has required researchers develop suitable study designs. This course proposes to qualify students to develop research projects in the field of Nursing in Central Sterile Service Departments, taking into account the rigor required for producing knowledge in this specialty. • To discuss and analyze different research designs related to the aseptic processing of health products and healthcare environment decontamination, with the goal of broadening students’ information based on the topic so that their practice can be critical and transformative. To mobilize graduate students’ capacity of using and developing research methods suitable for producing new consistent knowledge. School of Nursing (EE) São Paulo, Pinheiros campus 1. Analysis of published studies on the aseptic processing of health products and healthcare environment decontamination. 2. Basic research designs for demonstrating security against the presence of endotoxins, biofilms and microorganisms in processed health products. 3. Analysis of developing research projects about the aseptic processing of health products and healthcare environment decontamination, identifying their theoretical and methodological basis. Kazuko Uchikawa Graziano 27 ENC5932 2 The course lasts one week and meets on 3 consecutive days with 8 hours of work per day. Presentation of and ability to discuss a developing graduate research project, incorporating pertinent suggestions from the course. http://sites.usp.br/ee/

The proposal of this course is to create an adequate infrastructure for data collection and management of the studies carried out in the scope of Post-Graduation Program. In order to achieve this goal, students will have access to the world’s most widely used system for electronic data collection and data management in scientific research, known as REDCap (Research Electronic Data Capture). This course will provide best practices and real case examples for data management in REDCap. This course aims to present critical concepts and practical methods to support planning, collection, storage, and dissemination of data in clinical research to enhance security, reliability and quality to the data collected for research purposes. School of Nursing (EE) São Paulo, Pinheiros campus Principles of data management in scientific research; Recommended practices for development of questionnaires; Modalities for data collection in scientific research; Privacy, confidentiality and data security requirements of human research data; REDCap _ key concepts and applications in scientific research; International data standards and best practices for data dictionaries definitions; Effective data management: reports, data export, graphical visualization and data quality monitoring; Considerations for conducting web-based surveys; Hands-on training: REDCap projects development (classical and longitudinal) and application of the main REDCap features. Katia Regina da Silva 20 ENC5966 2 Hands-on exercises. http://sites.usp.br/ee/

All research is grounded in a theoretical perspective. Nursing knowledge is only built through the development and testing of theories and conceptual frameworks. The purpose of this course is to enhance students understanding of how nursing conceptual frameworks are used to guide nursing research. Students will be able to aplly the knowledge learned in this course to guide their proposed research. 1. Describe the relationship between nursing science, philosophy, theory development and research; 2. Examine selected nursing theories and their application to research; 3. Apply the process of theoretical substruction in the analysis of nursing theory testing research. School of Nursing (EE) São Paulo, Pinheiros campus Structure of knowledge in the discipline of nursing; The value and purpose of nursing theory; Tipes of theories; Selected conceptual frameworks and nursing theories and their application to guide research; Theoretical substraction of nursing theories. Rita de Cassia Gengo e Silva 22 ENC5967 2 Each student will select a published nursing theory testing research article and complete a theoretical substraction on the conceptual framework of the study. http://sites.usp.br/ee/

A Microbiome is a complex microbial community, which can inhabit a wide variety of environments, from the human gut, to soil, to food products. The study of these communities is done through Next Generation Sequencing, and its associated metadata. There is a large demand to have people correctly trained that can perform this analysis. This class will supply this demand by introducing the students to current analytical tools used for microbiome data analysis, through theoretical and practical classes, which will enable the student to conduct a final data analysis project (primary data or database available data). To provide theory and practical background on conducting microbiome data analysis. School of Pharmaceutical Sciences (FCF) São Paulo main campus Fundamentals concepts in microbiome related experimental design, fundamentals of sequencing library preparation, introduction to data analysis using Qiime, Picrust, Permanova, R, A’nvio etc. Christian Hoffmann 20 FBA5906 6 The class will be thought in English and may have the participation of invited international data analysts, to be announced opportunely. Students will be required to hand in a final paper based on the analysis they conduct throughout the semester. http://www.fcf.usp.br/english.php

Computational neuroscience is a research area in rapid development, comprehending several mathematical and computational techniques to model neurons and networks of neurons at different levels of detail. It is having growing importance in neuroscience, strengthening the interface between this science and so-called exact sciences. Given the interdisciplinary nature of the Physics Applied to Medicine and Biology Graduate Program, it is important that such a course exists to give the student an opportunity to learn the main methods and tools of computational neuroscience. To offer an introduction to the mathematical and computational methods used in theoretical studies in neuroscience. Faculty of Philosophy, Sciences and Letters at Ribeirão Preto (FFCLRP) Ribeirão Preto campus 1. Presentation of computational neuroscience. 2. Basic elements of neuroscience: neurons, synapses and neural circuits. 3. Neuron models I. integrate-and-fire model and its extensions. 4. Neuron models II. the Hodgkin-Huxley model. 5. Neuron models III. Conductance-based and compartmental models. 6. Neuron models IV. Reduced models and phase space analysis. 7. Models of synapses. 8. Models of networks of neurons. Antonio Carlos Roque da Silva Filho 25 5915756 6 Lists of exercises (40% of final grade); Computer projects (60% of final grade). https://www.google.com.br/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiBp_-p9NzYAhWHkZAKHY_oACkQFggnMAA&url=http%3A%2F%2Fwww.ffclrp.usp.br%2Fdown.php%3Fid%3D1430%26d&usg=AOvVaw3-C7BSHGAhorxoB-Rfx8dD

Magnetic resonance imaging (MRI) as neuroimaging modality has undergone major advances in recent decades. Several techniques has expanded the application areas of MRI, such as functional imaging, spectroscopy, angiography, among others techniques. The speed of this progress and its multidisciplinary character leads to a superficial overview of the use and understanding of fMRI. Therefore, an extensive discussion of this technique is important to provide a better understanding of the results in the study of biological systems, in particular due to the possibility to study the brain in a completely non-invasive way. The discipline aims to give a detailed view of the methodological aspects and recent applications of functional Magnetic Resonance Imaging (fMRI). Faculty of Philosophy, Sciences and Letters at Ribeirão Preto (FFCLRP) Ribeirão Preto campus 1. Principles of Magnetic Resonance Imaging. 2. Contrast mechanisms in Magnetic Resonance Imaging. 3. BOLD contrast. 4. Temporal and spatial properties of fMRI. 5. fMRI pre-processing. 6. Experimental design in fMRI. 7. Statistical analysis in fMRI. 8. fMRI applications in neuroscience. Carlos Ernesto Garrido Salmon, Renata Ferranti Leoni 25 5915768 4 P = Written Exam and/or S = Seminar https://www.google.com.br/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiBp_-p9NzYAhWHkZAKHY_oACkQFggnMAA&url=http%3A%2F%2Fwww.ffclrp.usp.br%2Fdown.php%3Fid%3D1430%26d&usg=AOvVaw3-C7BSHGAhorxoB-Rfx8dD