Genome science is integrated into a large variety of life science research, enabling plant scientists to gain insights on the cause of phenotypic variation, species evolution, crop domestication, etc. Understanding genome organization and evolution has been shown as an effective way to design strategies for gene discovery, functional studies, as well as for crop breeding. Indeed, the outcome of a genome project is not only the series of nucleotide sequences, but also the history, biology and possible applications that the sequence data tell us. This course aims to provide students an integrative view of plant genomics through the presentation of various genomics-related topics. This course aims to provide students an integrative view on plant genomics, updates on plant genomics, as well as to train students in evidence-based reflection. College of Bio-Resources & Agriculture Main Campus Students having studied plant genomics, molecular biology, and/or bioinformatics are welcome. Students’ interactive participation is required. Yung-Fen Huang 20 Wednesday 8,9 Agron7035 (621EM2080) 2 (College of Bioresources and Agriculture) Graduate Institute of Agronomy, Crop Science Division http://www.agron.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

As land plants are sessile organisms, they have evolved sophisticated defense mechanisms against various environmental stresses. To survive and reproduce, plants adapt to stresses by changing their physiology and gene expression. Insect herbivores are one of major biotic stresses to plants. As plants are the main nutrient sources for these insects, plants have evolved with a number of defense mechanisms to protect themselves. In this course, we will explain crop-insect interaction from several aspects (molecular mechanisms, traits, ecology, evolution, and practical farming management). Help students to understand the concept of Crop-Insect Interaction and offer the opportunity for writing paper and oral presentation College of Bio-Resources & Agriculture Main Campus Course Outline: 1. An overview of Crop -Insect Interactions 2. Plant traits to insects 3. Insect traits to plants 4. Tritrophic interactions 5. Plant community ecology and evolution 6. Implications of Crop -Insect Interactions Wen-Po Chuang 30 Monday 3,4 Agron5091 (621EU6760) 2 (College of Bioresources and Agriculture) Department of Agronomy,
(College of Bioresources and Agriculture) Graduate Institute of Agronomy, Crop Science Division http://www.agron.ntu.edu.tw/main.php?lang=en&Trad2Simp=n

Nano/micro engineering technology has increasing impacts in biomedical research. The manipulation and measurement of this scale, ie,several hundred nanometers down to atomic resolution, is closely related to the dimension of many important biomolecules and the sampling of the volume down to this size has significant biomedical implications.The full understanding of a biological system is the first step of being able to control or even manipulate it in the future. In this course, we will introduce some basic nano/micro engineering techniques used at our lab for the biosensing, analysis, and manipulation at molecular, cellular and tissue levels. In previous years, the course is undergone by a weekly class with half part in literature discussion and the other half for technique introduction. In this year, we have made some changes by decreasing the literature discussion with most literature discussion dedicated on the identification of a biomedical issue; on the other hand, the related nano/micro techniques are introduced in more details and accompanied by approperiate demonstration. The choice of a term project has been changed from technique-based to biomedical issue-oriented.Instead of picking a technique and finding a biomedical application, the students have to identify a central question in biomedical research or come up with a device design to facilitate biomedical test, and then find the appropriate techniques to answer or fullfil the purpose and intention raised in their project. This will help students to pick up all the nano/micro engineering techniques which meet the biomedical research requirement. And with the guidance of the need in biomedical research, students will be able to foresee the future direction of technology advancement in assisting the biomedical research and practice. 1. Encourage the interdisiplinary discussion and enlarge the understanding of the core biomedical issues from a multidisciplinary view. 2. Gaining in-depth experience from a hands-on project. College of Engineering Main Campus In this semester, we will work on the theme of “Digital Nano Array” with microlabs on nanofabrication, measurement, and analysis. The students will be set into 2 groups for a hands-on term project. The students can pick an issue in biomedical research or practice. The focus given at this semester is “pre-processing of raw sample for subsequent biomolecule sensing.” The students need to specify their purpose and research methods and give an oral presentation on April 12. The complete experimental results will be delievered at the final report, which is on Jun 12, along with a paper report detailing the procedures and results. Chii-Wann Lin 10 Friday A,B,C Biomed7038 (548EM0650) 3 (College of Engineering) Graduate Institute of Bomedical Engineering,
Non-degree Program: Nano-Technology Engineering,
(College of Electrical Engineering and Computer Science) Graduate Institute of Biomedical Electronics and Bioinfornatics http://bme.ntu.edu.tw/english/

Over 3000 international investment agreements (IIA) currently operates through Bilateral investment treaties (BITs) and investment protection provisions of free trade agreements (FTAs). Investment agreements are concluded by the investor’s home country and the host country. Its aim is to protect the investor and investment made in the territory of the host country. By the nature of mixing public-private law, investment treaties usually have a wider implication for the domestic regulatory regime of host states. Notable examples include trade, tax, intellectual property, renewable energy, environment and public health policies. How to balance investor’ rights and the host state’s right to regulate in public mattes has thus become a topical issue in investment relations. On dispute settlement, foreign investor are given the direct rights to use international arbitration challenging the host state’s measures. The arbitral rules of the ICSID (International Centre for Settlement of Investment Disputes) and United Nations Commission International Trade Law Arbitration Rules (UNCITRAL) are the two rules which have been most commonly used. As practiced, the number of investor-State arbitrations has mushroomed as hundreds of millions of dollars have been awarded as compensation remedies. Investment arbitration usually affects a wider public interest of a host state and thus has invited hot debates within international economic community. Tentative topics to be discussed follow. (1) Overview of International Investment Law Proliferation in Asia (2) Definition on investors and investments (3) Non-discrimination treatment: National Treatment; Most Favoured Nation (4) Indirect expropriations and right to regulate (5) Fair and equitable treatment: the emerging proportionality principle? (6) Full protection and security/ umbrella clause (7) Cross-cutting Issues in Investment Law Asia Perspective on Sustainable Environment and Public Health (8) BIT dispute settlement in East Asia and the dispute settlement in the investment chapter of the Trans-Pacific Partnership (TPP) (9) Introduction to ICSID arbitral rules(I): ICSID Jurisdiction, applicable law and interim measure (10) Introduction to ICSID arbitral rules(II):Challenge and annulment procedures (11) Introduction to ICSID arbitral rules(II): Enforcement and sovereign immunity The course is designed to help students establish the basic capacity to deal with issues on foreign investment law. It will also help students have good basic knowledges of investment arbitration. College of Engineering Main Campus Class sessions will be conducted by lectures, students’ presentations and discussions. 2. Each student is required to pick up a topic and make presentation in class. The topic shall be approved by the instructor. 3. The Power-Point slides should be delivered to the instructor, teaching assistant and students via e-mail and ceiba three days prior to presentation. 4. Each student is required to write a term paper at the end of the semester. The topic of the term paper needs to be approved by the instructor. The 10-page full-paper should use blue book citation. 5. Attendance for all classes and active class participation is strongly encouraged. In no event, the participants should miss two classes without good reason. 6. The course evaluation will be based on class participation (including attendance and discussion) (40%), the presentation (30%) and the final term paper (30%). Tung-Wu Lu 15 Wednesday 2,3,4 Biomed7054 (548EM0910) 3 (College of Medicine) Graduate Institute of Occupational Therapy,
(College of Engineering) Graduate Institute of Bomedical Engineering,
(College of Medicine) Graduate Institute of Occupational Therapy
*Registration eligibility: graduate students.
http://bme.ntu.edu.tw/english/

This class provides an introduction to the interactions between cells and the surfaces of biomaterials. The course covers: surface chemistry and physics of selected metals, polymers, and ceramics; surface characterization methodology; modification of biomaterials surfaces; quantitative assays of cell behavior in culture; biosensors and microarrays; bulk properties of implants; and acute and chronic response to implanted biomaterials. General topics include biosensors, drug delivery, and tissue engineering. This class provides an introduction to the interactions between cells and the surfaces of biomaterials. The course covers: surface chemistry and physics of selected metals, polymers, and ceramics; surface characterization methodology; modification of biomaterials surfaces; quantitative assays of cell behavior in culture; biosensors and microarrays; bulk properties of implants; and acute and chronic response to implanted biomaterials. General topics include biosensors, drug delivery, and tissue engineering. College of Engineering Main Campus Feng-Huei Lin 40 Tuesday 2,3,4 Biomed5001 (548EU0110) 3 *Registration eligibility: graduate students.
(College of Engineering) Graduate Institute of Bomedical Engineering,
(College of Engineering Ph.D.Program of Greem Materials and Precision Devices,
Non-degree Program: Nano-Technology Engineering http://bme.ntu.edu.tw/english/

Overview 課程概論 The environment influences organisms profoundly. It affects their present-day ecology (determining where they live and how many can survive there) and, through natural selection acting over past generations, influences their form and adaptations. Present day human-induced changes to the environment are also responsible for endangering species and even driving them to extinction. This course introduces the basic principles and the applications of ecology at different levels of ecosystems (i.e. individual-, population-, community-, ecosystem-, regional and global scales). The ecological theories will be illustrated with examples in order to enable better understanding of the links between the environment and organisms as well as the biological interactions and human-induced threats at each level of ecological organisation. The present course will be concluded with the introduction of biodiversity management, i.e. conservation, restoration and sustaining biodiversity, global ecological crisis, and the economical and socio-political dimensions of nature and environmental management. (1) Introduce the basic principles of ecology and its applications at different levels of ecosystems (i.e. individual-, population-, community-, ecosystem-, regional and global scales) (2) Explain how the environment affects organisms in terms of their present-day ecology (determining where they live and how many can survive there) and, through natural selection acting over past generations, influences their form and adaptations (3) Describe patterns of biological interactions and adaptations (4) Describe the causes and consequences of human-induced threats at different levels of ecological organisation (5) Illustrated ecological applications to different levels of ecosystems with published examples (6) Explain the value of biodiversity to human and biodiversity management, i.e. conservation, restoration and sustaining biodiversity (7) Introduce regional and global ecological crisis and ecological management (8) Introduce the economical and socio-political dimensions of nature and environmental management College of Bio-Resources & Agriculture Main Campus Grading policy: Assignments and continuous assessment (10%) Project presentation (30%) Class tests (20%) Final examination (40%) Rita S. W. Yam 110 Thursday 5,6,7 BSE2029 (602E27800) 3 (College of Bioresources and Agriculture) Department of Bioenvironmental Systems Engineering,
Non-degree Program: Ecological Engineering http://www.bse.ntu.edu.tw/english/super_pages.php?ID=english

Course description：With recent advances in nanotechnology, the practical knowledge of quantum mechanics will be introduced in this engineering course. Starting from the fundamental postulates of quantum mechanics, I introduce basic techniques for solving the Schroedinger equations for simple systems. Then I move to more advanced techniques using different kinds of approximation. The contents are 1. Postulates and Schroedinger equation. 2. Simple systems, free particle, 1D problems. 3. Harmonic oscillators, simple rotors. 4. Central potential problems, hydrogen atoms. 5. Gaussian wave packets. 6. Semi-classical approximation. 6. Adiabatic approximation. 7. Perturbation theory. 8. Variational method. 9. Numerical methods. 10. Special topics. Grades: Midterm (30%), Final (30%), Homework (40%) Text Book & References:　 S. Gasiorowicz, Quantum Physics (John Wiley, 2003, 3rd edition) D. J. Griffiths, Introduction to Quantum Mechanics (Pearson, 2005, 2nd edition) Hagelstein and Orlando, Introductory Applied Quantum and Statistical Mechanics (John Wiley, 2004) 趙聖德: 應用量子力學. 五南出版社, 2010年 (in Chinese) College of Engineering Main Campus Sheng-Der Chao 20 Thursday 7,8,9 AM7035 (543EM4740) 3 (College of Engineering) Graduate Institute of Applied Mechanics http://www.iam.ntu.edu.tw/English/EN-homepage/homepage-Frameset.htm

課程名稱: 細胞微機電及微流體導論 (Introduction to Cellular BioMEMS and Biomicrofluidics) 1.Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality. 2.Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis. 3.BioMEMS: Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing. 4.Microfluidics: scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media. 5.Special topic: Cell-based chip for biotechnology – bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping. 6.Special topic: BioMEMS for cell biology – substrate dependency of cells, cell-cell contact, cell migration. 7.Special topic: Tissue microengineering – 3D culture, angiogenesis, vasculogenesis, organ on a chip. (1) Introduce how to use basic mechanics to explain cell and tissue mechanics. (2) Explain how to apply cell mechanics to the design of BioMEMS and Biomicrofluidic devices (3) Understand the applications of BioMEMS and Biomicrofluidics in medical applications College of Engineering Main Campus Yu-Hsiang Hsu 20 Tuesday 7,8,9 AM7166 (543EM5310) 3 Non-degree Program: Nano-Technology Engineering,
(College of Engineering) Graduate Institute of Applied Mechanics http://www.iam.ntu.edu.tw/English/EN-homepage/homepage-Frameset.htm

Microelectromechanical Systems (MEMS) enable tiny devices or systems that can realize functions not easily achievable via transistor devices alone. This course focuses on the physical principles, tools, methodologies needed to properly model various types of MEMS sensors that are extensively used in our daily life. In addition, characterization of such MEMS sensors using open-source hardware will be covered through several hands-on laboratory sessions. College of Engineering Main Campus Experiments on Electronics Wei-Chang Li 16 Tuesday 7,8,9 AM7174 (543EM5370) 3 (College of Engineering) Graduate Institute of Applied Mechanics http://www.iam.ntu.edu.tw/English/EN-homepage/homepage-Frameset.htm

This course is to give an overview of circulatory biomechanics from the standpoints of engineering, physiology, and medical sciences. Experimental results from advanced clinical researches are used as examples and served as the guide to new focused research areas with great clinical values. Introduction to Physiological Fluid Dynamics Medical Terminology Physiological Properties of Human Body and Blood Rheology Dynamics of Circulatory System Relation of Cardiovascular Diseases (CVD) to Fluid Dynamics Mechanics of the Heart Principles of Ultrasound for BioFluid Research (Experiment 1) Arterial Fluid Dynamics and Hemodynamics(Experiment 2) Mechanical Properties of Arterial Vessels
(Experiment 3) Venous Fluid Dynamics Fluid Dynamics of Micro-circulation (Experiment 4) Fluid Dynamics of Pulmonary circulation Artificial Organs (Experiment 5) Grades: Literature reviews (Reports *3: 50%) Lab. Results & Discussion (*5; 50%) Text Book & References: 1. Biomechanics: Circulation (text book) by Y.C. Fung (Springer) 2. Biomedical Engineering Principles by David Cooney (Marcel Decker) 3. Biomechanics: Motion, Flow, Stress and Growth by Y.C. Fung 4. Blood Flow through Organs and Tissues by Bain and Harper 5. Cardiovascular Fluid Dynamics by Huang and Normann College of Engineering Main Campus Yio Wha Shau 20 Wednesday A,B,C AM7102 (543EM6230) 3 (College of Engineering) Graduate Institute of Applied Mechanics http://www.iam.ntu.edu.tw/English/EN-homepage/homepage-Frameset.htm

Course Syllabus: This design studio aims to bring the operation of spatial scenario into the field/work of the real world, and further amplify the analyses of social characters, landscape textures, and local narratives to construct a design methodology that is based on the site-specific and community-oriented mode of placemaking. The field operation is focused either on Taipei’s Shezi Island or Gah-lah, and the students will decide the location(s) of design intervention after individual and group visits. The possible sites include: 1. Li-zhongji courtyard house, Fu-zhou Settlement, Shezi Island 2. The route along the Waterfront Houseboat-Mouth of the Theater, His-zhou-di Settlement 3. The route along the embankment wall bike trail ramp-Li He-hsing House, His-sha-wei Settlement 4. Wanhe Garden, Fuzhou Settlement The Gah-lah site of Taipei’s south Wanhua District will be an in-situ transformation of a former dormitory bungalow interior into a shared community space. 5. Institution zoning #9 bungalow house The operation in either of the two fields is grounded on the spatial and social foundations established from previous practicum studios, and may involve hands-on construction. The design attitude of this studio is akin to the value revealed in the book title and case studies of Design Like You Give a Damn, and can be regarded as an intention of socially engaged design. Field/work is a learning site, and design is a process of spatial action. We will also appropriate the dialectics of ‘space of representation’ and ‘representation of space’ by Henri Lefebvre as the inception of understanding the field. But the building mode of the ordinary, or self-built/illegal buildings in Shezi Island or Gah-lah is rather different from the architectural production under the modernistic contract. The buildings are not necessarily constructed following the patent ‘representation’ (or architectural drawings, models, or 3D simulations), and the typology and meaning of their spatial symbols need to be researched and surveyed to become local knowledge. To ‘register’ or record the existing building patterns and spatial structures of the field can be regarded as a reverse typifying of ‘representation of space,’ that is, the ‘spaces of representation’ produced by ordinary people’s ‘spatial practices’ must be endowed with the source of meanings for the ‘representation of spaces’ so that we can extract the patterns, types, or critiques which the ensuing phases of the spatial production depend upon. When we systemize the representations of ordinary spatial practices, we may be able to construct a site-specific pattern language and develop the spatial scenario relevant to the design approach. This studio also encourages participant students to submit design proposals for New Taipei City’s ‘Social Housing for the Youth’ competition, and it will be further discussed through a collective decision making process. 1. learning the methodology of placemaking in design 2. hands-on practices and field researches of the real sites 3. collaborative design and community participation College of Engineering Main Campus 1. full participation and design practices 2. field works and representations 3. drawings, models, and presentations of different design phases 15 Tuesday A,B,C,D Friday A,B,C,D BP5016 (544EU1790) 6 *Registration eligibility: juniors and above.

(College of Engineering) Graduate Institute of Building & Planning http://en.bp.ntu.edu.tw/

This course will cover topics in particle technology, with an emphasis on the design and modeling of equipment for particle manufacture, separation and handling. We discuss the crystalline state of matter, crystal size distributions, crystal nucleation and growth, design of crystallizers and filters, fluidization, slurry transport, particle mixing and segregation, and particle size reduction and enlargement. Students will work in small groups to complete a design project. Several homework assignments will be given over the course of the semester. Exams will be open-notes. Grades will be determined approximately as follows: Homework 20% Semester Project 30% Mid-term exam 20% Final exam 30% References: Introduction to particle technology (2nd ed.) by Martin Rhodes Industrial crystallization : fundamentals and applications by Alison Emslie Lewis, Marcelo Martins Seckler, Herman Kramer and Gerda Van Rosmalen Crystallization : Basic Concepts and Industrial Applications. Edited by Wolfgang Beckmann College of Engineering Main Campus This class is suitable for senior undergraduate or graduate students in chemical engineering or a related field. Jeffrey Daniel Ward 50 Monday 7 Wednesday 8,9 ChemE5057 (524EU0210) 3 (College of Engineering) Graduate Institute of Chemical Engineering,
(College of Engineering) Department of Chemical Engineering http://www.che.ntu.edu.tw/che/?lang=en