Organizers Dr. Hsou-min Li College of Medicine 1. A two-hour exam will be conducted in a close-book and in-class format for both the mid-term and final exams. Some instructors may also use in-class quits or homework for grading. 2. Each lecture will weight the same in your final grade. 3. Students with a final grade ? 70 are regarded as “pass”. Students who fail the course cannot be granted the course credits and should retake the course if the course required by their program. SHU-CHUN TENG Monday 34 Thursday 78 PTMP8015 4

The Stem Cell Biology Course is primarily consisted of a series of lectures which covers from basics of the general biology of stem cells to a more in-depth discussion on various stem cell types: embryonic stem cells, adult somatic stem cells and cancer stem cells, and finally to some of their potential clinical application/implication. For evaluation, students are required to write a review essay on designated research topics so that they can horn their skills in the search, organization and critical assessment of literatures. College of Medicine (i) A written essay on a selected topics 40 % (ii) A short presentation on a selected topics (10 min) 40% (ii) Attendance 20 % SHU-CHUN TENG Thursday 789 PTMP8025 3

THIS COURSE WILL PRESENT AN INTRODUCTION TO PROCESS DYNAMICS AND CONTROL. STUDENTS WILL LEARN HOW TO CONSTRUCT DYNAMIC MODELS OF PROCESS SYSTEMS, HOW TO ANALYZE PROCESS DYNAMICS USING LAPLACE TRANSFORMS AND TRANSFER FUNCTIONS, THE CHARACTERISTIC RESPONSES OF DYNAMIC PROCESSES, AND THE DESIGN AND IMPLEMENTATION OF FEEDBACK CONTROL. STUDENTS WILL ALSO LEARN TO USE COMPUTER SOFTWARE TO MODEL PROCESS DYNAMICS AND CONTROL. College of Engineering Jeffrey Daniel Ward Monday 2 Wednesday 34 ChemE4007 3

Please refer to the attached syllabus. College of Management Please refer to the attached syllabus. Yan-Shing Chen Friday 789 Fin8029 3

This course is about the econometric analysis of financial time series. We will cover some popular and useful methods and their empirical applications. These methods include ARIMA processes, GARCH models, stochastic volatility models, and continuous-time models. If time is allowed, we will also look at copula methods and their applications in finance. College of Management First priority: Master or PhD studnents in Finance CHUNG-MING KUAN Monday 789 Fin8036 3

Classroom: IBMS TIGP classroom (8F, New Building) Coordinator:徐志文 College of Medicine SHU-CHUN TENG Tuesday 67 PTMP8011 2

Design and analysis of algorithms for biologists College of Medicine Grades: Midterm exam 50%. Final exam 50%. SHU-CHUN TENG Friday 789 PTMP8012 3

In the first semester: ?? Learn the background knowledge of information retrieval. ?? Learn the knowledge about Naive Bayes classification. ?? Be able to extract blog entries; identify opinion words and sentences. ?? Prepare training instances for the recommendation engine. ?? In the second semester: ?? Develop the recommendation engine. ?? Develop a fancy web interface. College of Management LING-CHIEH KUNG IM4001 2

1. INTRODUCTION 2. PROMISES OF STEM CELL RESEARCH 3. DEVELOPMENTAL CELL BIOLOGY 4. EMBRYONIC STEM CELLS 5. THERAPEUTIC CLONING 6. PLASTICITY OF STEM CELLS 7. STEM CELL HOMING AND ENGRAFTMENT 8. STEM CELL FATE: INTRINSIC AND EXTRINSIC FACTORS 9. STEM CELLS AND CANCERS 10. HEMATOPOIETIC STEM CELLS 11. MESENCHYMAL STEM CELLS 12. NEURONAL STEM CELLS 13. LIVER STEM CELLS 14. CORNEAL STEM CELLS College of Bio-Resources & Agriculture Thursday 678 Biot8002 3 The upper limit of the number of non-majors: 20.

This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. 1. Understand amino acids and protein structures. 2. Modern approaches to resolve protein structure. 3. Protein structure and function. 4. Software-based analysis of protein sequence. 5. Bioinformatic theories 6. Current developments of bioinformatics methods. College of Bio-Resources & Agriculture This class will be taught in English. CHII-SHEN YANG Friday 678 Biot8003 3 The upper limit of the number of non-majors: 15.

IT IS NOW CLEAR THAT LOTS OF NON-CODING RNAS IN THE GENOME ARE FUNCTIONAL AND VERY POWERFUL IN REGULATING GENE ACTIVITIES AND DEVELOPMENTAL PROCESS. DEPENDS ON THE BACKGROUND OF THE STUDENTS, AROUND 1/3 OF THE LECTURES WILL BE GIVEN BY THE INSTRUCTOR FOR INTRODUCING BASIC CONCEPTS IN NON-CODING RNA REGULATED GENE SILENCING, INCLUDING THE POST-TRANSCRIPTIONAL REGULATION BY SIRNA, MICRORNA AND REPRODUCTIVE ORGAN SPECIFIC PIRNAS. THESE WILL COVER THE PHYSIOLOGICAL PROCESS INCLUDING GENOMIC IMPRINTING, SEX CHROMOSOME COMPENSATION, SILENCING OF ENDOGENOUS RETROTRANSPOSONS AND STEM CELL BIOLOGY. IN ADDITION, THE INVOLVEMENT OF NON-CODING RNA RELATED REGULATORY MECHANISMS IN CARCINOGENESIS WILL BE DISCUSSED. FOR THE REST OF THE CLASSES, STUDENTS WILL BE ASSIGNED THE MOST UPDATED ORIGINAL RESEARCH PAPERS AND CONFERENCE ARTICLES AS WELL AS THE MILESTONE PUBLICATIONS. THEY WILL BE RANDOMLY DIVIDED INTO 2 GROUPS FOR EACH ASSIGNMENT. ONE GROUP WILL BE PRESENTING THE ARTICLES AND STUDENTS IN THE OTHER GROUP ARE EXPECTED TO CHALLENGE THE PAPERS FROM THE EXPERIMENTAL DESIGN, THE METHODOLOGY TO THE INTERPRETATION OF THE DATA. STUDENTS IN THE 1ST GROUP SHOULD DEFEND FOR THE PAPERS AS IF IT’S THEIR MANUSCRIPT. STUDENTS FROM THE 2ND GROUP SHOULD ALSO PROVIDE CONSTRUCTIVE ADVICE AS HOW TO IMPROVE THE MANUSCRIPT SO THAT IT CAN BE PUBLISHED IN A HIGHER IMPACT JOURNAL. College of Bio-Resources & Agriculture PREFERABLY HAVING STUDIED ONE OF THE FOLLOWING SUBJECTS: (INTRODUCTORY) EPIGENETICS, SPECIAL TOPICS IN REPROGRAMMING, GENETICS AND EPIGENETICS IN GERM AND STEM CELLS Friday 34 Biot8014 2

COURSE DESCRIPTION: THIS HALF-YEAR GRADUATE COURSE AIMS TO INTRODUCE BASIC GENE SILENCING CONCEPTS AND RESEARCH TECHNIQUES AVAILABLE TO ADDRESS GENE SILENCING QUESTIONS IN PLANT AS WELL AS OTHER ORGANISMS. STUDENTS ARE EXPECTED TO DEVELOP THE ABILITY TO CRITICALLY EVALUATE AND INTERPRET PUBLISHED RESEARCH ARTICLES. THEY WILL ALSO LEARN TO EXTRACT INFORMATION FROM INTERNATIONAL CONFERENCES BY LISTENING TO EXPERTS OF EACH FIELD INTRODUCING THEIR RESEARCH. OUTLINE: 1. INTRODUCTION – OVERVIEW 2. SENSE CO-SUPPRESSION IN PLANT 3. TRANSGENE CO-SUPPRESSION IN ANIMALS 4. PLANT VIRUS RESISTANCE VS. CO-SUPPRESSION 5. TRANSCRIPTIONAL GENE SILENCING (TGS) 6. POST-TRANSCRIPTIONAL GENE SILENCING (PTGS) 7. VIRUS-INDUCE GENE SILENCING (VIGS) 8. SILENCING SIGNAL TRANSPORTATION 9. SMALL RNA 10. SIRNA PATHWAY 11. MIRNA PATHWAY 12. FUNCTION OF DICER 13. FUNCTION OF RNA-INDUCE SILENCING COMPLEX (RISC) 14. FUNCTIONS OF DICER-LIKE PROTEINS (DCLS) IN PLANT 15. DCL1 VS. MIRNA BIOGENESIS 16. FUNCTION OF DCL2 AND NAT-SIRNA 17. FUNCTION OF DCL3 AND DNA METHYLATION 18. FUNCTION OF DCL4 AND TRANS-SIRNA 19. ARGONATURE FAMILY 20. SUPPRESSION OF GENE SILENCING 21. RNAI TECHNOLOGY 22. MIRNA TECHNOLOGY College of Bio-Resources & Agriculture Monday 234 Biot8016 3