Cancer is one of the main causes of illness-related death in many countries, including Brazil. Despite current therapeutic advances, the prognosis of patients diagnosed with this pathologic condition is still poor. Thus, an effective method for controlling cancer is preventing its development, which can be achieved by the diet or by the intervention with nutrients and/or BFCs in subjects with high risk of cancer development. Several genes have shown altered expression during carcinogenesis and are considered targets for nutrients and/or bioactive compounds in the context of cancer prevention. The understanding of the mechanisms involved in the modulation of gene expression by nutrients and/or BFCs, is fundamental for the design of research projects that deepen the knowledge of graduate students in Food Science and related areas, and for the development of strategies for nutritional intervention in the context of cancer prevention. To empower graduate students to understand how nutrients and bioactive food compounds (BFCs) modulate the expression of genes involved in cancer’s physio-pathology. School of Pharmaceutical Sciences (FCF) São Paulo main campus 1) Basic “OMICS” tools for Nutrigenomics studies; 2) Molecular targets for cancer chemoprevention; 3) Functional foods and cancer prevention; 4) Modulation of the epigenetic processes by nutrients and BFCs; 5) Modulation of the expression of micro-RNAs by nutrients and BFCs; 6) Molecular aspects of the relationship between obesity, nutrition and cancer prevention Fernando Salvador Moreno, Thomas Prates Ong, Jens Uwe Marquardt 20 FBA5897 2 The discipline will have the collaboration of Dr. Renato Heidor, specialist of The Diet Nutrition and Cancer Laboratory, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of S_o Paulo. Participation in the discussions. http://www.fcf.usp.br/english.php

A Microbiome is a complex microbial community, which can inhabit a wide variety of environments, from the human gut, to soil, to food products. The study of these communities is done through Next Generation Sequencing, and its associated metadata. There is a large demand to have people correctly trained that can perform this analysis. This class will supply this demand by introducing the students to current analytical tools used for microbiome data analysis, through theoretical and practical classes, which will enable the student to conduct a final data analysis project (primary data or database available data). To provide theory and practical background on conducting microbiome data analysis. School of Pharmaceutical Sciences (FCF) São Paulo main campus Fundamentals concepts in microbiome related experimental design, fundamentals of sequencing library preparation, introduction to data analysis using Qiime, Picrust, Permanova, R, A’nvio etc. Christian Hoffmann 20 FBA5906 6 The class will be thought in English and may have the participation of invited international data analysts, to be announced opportunely. Students will be required to hand in a final paper based on the analysis they conduct throughout the semester. http://www.fcf.usp.br/english.php

This course deals with formation models for the main geotectonic provinces, how they are set in the past and in the present; the main characteristics of the continental and oceanic lithosphere using geophysical data and how to integrate this data to the tectonic knowledge of South American plate. This course aims to provide information on the main geotectonic provinces of South America and about the geophysical surveys in great scale. It is expected that the students can use all the information to infer relations among geology and geophysics. Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG) São Paulo main campus 1. South American plate contextualization. 2. Continental and oceanic lithosphere. 3. Craton: concept and examples, South American Cratons. 4. Orogens: concept and examples; mobile belts: BSB, Paraguay-Araguaia, Mantiqueira, Borborema. 5. Patagonia. 6. Andes. 7. Basin: formation basic concepts; South American basins: Paran_, Chaco, Potiguar, Santos, Rec_ncavo- Tucano, Magalh_es. 8. Oceanic lithosphere. 9. Paleomagnetism. 10. Heat flow. 11. Crust and lithosphere thickness. 12. Effective lithosphere thickness. 13. Geoid. 14. Gravity. 15. Magnetic field. 16. Stress. 17. Seismicity at the South American and Nazca plates. Marta Silvia Maria Mantovani, Yara Regina Marangoni, Ricardo Ivan Ferreira da Trindade 30 AGG5937 9 Tests and seminars. http://www.iag.usp.br/international/

Phycology is a broad area that studying a wide diversity of life forms, from prokaryotic organisms (cyanobacteria) to different lineages of eukaryotes. The knowledge about biodiversity, biology and biotechnological applications have advanced intensively in recent years in Brazil and abroad. Therefore, the focus of this course is to keep the graduate students aware of these advances, and promote presentations and discussions of diverse phycological topics in English. 1. Present and discuss phycological topics and related areas in order to provide a broad and updated knowledge to the students. 2. Expose research projects and seminars for discussion and suggestions, enabling the exchange of information between the projects developed by the students. 3. Offer the student an environment for training oral presentations and scientific debates in English. Institute of Biosciences (IB) São Paulo main campus Diverse and current themes on Phycology and related areas, including classical and molecular taxonomy and systematics, biogeography and phylogeny, ecology, physiology, chemistry, genetics, omics sciences, mariculture, environmental education and biotechnological applications of algae. The course will be based on oral presentation of seminars and discussions. Mariana Cabral de Oliveira, Fanly Fungyi Chow Ho 20 BIB5755 2 All students should present at least one seminar in English (including the oral presentation and slides) based on their research project or a related subject. http://www.ib.usp.br/en/

Integrate concepts from different areas of plant biology and update about the last generation experimental approaches Improve the knowledge about current topics, experimental approaches and techniques in plant biology Institute of Biosciences (IB) São Paulo main campus The subject will approach theoretical topics about gene expression regulation, genetic transformation, molecular markers, genomics, genetic and metabolic engineering, as long as technical aspects. The content will be introduced from the system biology point of view in an integrative and interdisciplinary manner, aiming the understanding of physiological and breeding processes Marie Anne van Sluys, Maria Magdalena Rossi 20 BIB5764 8 Class participation, lectures and tests http://www.ib.usp.br/en/

The goal of Seminars in Parasitology is to encourage students to discuss work from different parts of this large field of knowledge, fostering the learning and the discussion of a broad base of current scientific issues. The opportunity of discussing and interacting with authors is highly enriching and facilitates the retention of knowledge. The possibility of directly asking the authors questions fosters the development of a critical spirit in the student. Biomedical Sciences Institute (ICB) São Paulo main campus Talks will be presented by researchers active in the many subfields of Parasitology and related disciplines. These researchers will mostly come from other departments and universities, but some might be professors, postdoctoral fellows or young researchers from our own department. The speakers list will be announced in advance, at the start of the semester. Carlos Eduardo Winter, Gerhard Wunderlich, Giuseppe Palmisano 30 BMP5735 4 * Assessment will be based on frequency of attendance; students who have missed a talk can make up their attendance record by writing a satisfactory one-page (maximum) essay about one of the talks they have not missed. Up to three absences can be nullified in this manner. https://ww2.icb.usp.br/ing/

The goal of every astrophysical model is to provide a quantitative interpretation of astrophysical observations. This discipline is hence fundamental to students which aim to pursue their MSc, PhD and post-graduate studies in Astrophysics. Study the basic processes involved in the production of radiation that we receive from celestial bodies, as well as the interaction of this radiation with intervening matter. Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG) São Paulo main campus Radiative Transfer. Radiation fields. Polarization of Light. Radiation from charged particles. System of Particles. Special Relativity. Bremsstrahlung. Synchrotron Radiation. Compton Scattering. Plasma Effects. Atomic radiative and collisional transitions. Astrophysical line emission processes. Stellar spectral line formation. Antonio Mario Magalhaes 30 AGA5731 11 http://www.iag.usp.br/international/

The aim of this course is the study of stellar populations in our Galaxy, and in other galaxies. The populations in our Galaxy, from the halo, bulge, thin and thick disks, can be studied in terms of their ages, metallicities, abundances, kinematics, and their evolution in time and space. We also introduce the basic ingredients of evolution of galaxies: stellar evolution, chemical evolution, and spectroscopy of individual stars and composite stellar populations. Different types of galaxies are studied: elliptical, spiral, irregular galaxies, and HII regions. The program is concluded with the analysis of composite spectra of galaxies, using codes from the literature. The distribution of stellar populations in galaxies is studied, making that these studies comprehend most objects in the Universe: the galaxies studied through the stars that form them. In astrophysics, it is therefore a fundamental course. Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG) São Paulo main campus Basics of stellar evolution. Basics of nucleosynthesis. Formation and abundances of chemical elements. Basics of stellar dynamics. Models of chemical evolution of the Galaxy and galaxies in general. Evolution of stellar populations in the Galaxy. Star formation rate in galaxies, initial mass function. Stellar population synthesis and the Hubble diagram. Spectroscopy of composite stellar populations. Stellar populations in spiral, elliptical, lenticular, irregular and spheroidal dwarf galaxies. Beatriz Leonor Silveira Barbuy 25 AGA5740 11 http://www.iag.usp.br/international/

The observational activity is one of the pillars of Astrophysics, continuously feeding the theoretical elaboration. Observational training is essential both to researchers who produce the data as to theorists who should know evaluate them critically. Give to the graduate student fundamental notions of the instrumentation used in Astrophysics, as well as on observational techniques, data acquisition and reduction. In particular, give to the student conditions to plan the use of instrumentation to achieve specific scientific goals. Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG) São Paulo main campus Effect of Earth’s atmosphere on observations in the optical and infrared; Telescopes and image quality; Effects of the interstellar medium; Detectors; Techniques of radio astronomy; Photometry; Spectroscopy; Elements of polarimetry ; Data acquisition handling; Space astronomy – X-rays Roberto Dell’Aglio Dias da Costa, Marcos Perez Diaz, Jorge Luis Melendez Moreno 30 AGA5802 11 Tests and practical exercises http://www.iag.usp.br/international/

In this course we will discuss the main scenarios for the formation and evolution of galaxies in order to enable the students to know the main recent advances in the area and also to expose them to the questions and challenges still open. Some content discussed in other disciplines, especially Extragalactic Astronomy, will be briefly reviewed. The question of the origin and evolution of galaxies is one of the most important research topics in the present day in extragalactic astronomy and cosmology, both theoretically and observationally. The techniques used are quite varied and useful in various areas of research. The course should provide the elements for students to track progress in this area Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG) São Paulo main campus Review of the properties of galaxies: structure, stellar populations, scale relations, dependence on the environment. Review of cosmology concepts relevant to the course. Gravity instability and structure formation. The first stars. The reionization. Semi-analytical models of galaxy formation. Star formation. Chemical evolution. Photometric-photometric evolution. Mergers of galaxies. Evolution of Morphology. Analysis of observational data. Laerte Sodre Junior, Gastao Cesar Bierrenbach Lima Neto, Paula Rodrigues Teixeira Coelho 25 AGA5906 11 http://www.iag.usp.br/international/

Computational neuroscience is a research area in rapid development, comprehending several mathematical and computational techniques to model neurons and networks of neurons at different levels of detail. It is having growing importance in neuroscience, strengthening the interface between this science and so-called exact sciences. Given the interdisciplinary nature of the Physics Applied to Medicine and Biology Graduate Program, it is important that such a course exists to give the student an opportunity to learn the main methods and tools of computational neuroscience. To offer an introduction to the mathematical and computational methods used in theoretical studies in neuroscience. Faculty of Philosophy, Sciences and Letters at Ribeirão Preto (FFCLRP) Ribeirão Preto campus 1. Presentation of computational neuroscience. 2. Basic elements of neuroscience: neurons, synapses and neural circuits. 3. Neuron models I. integrate-and-fire model and its extensions. 4. Neuron models II. the Hodgkin-Huxley model. 5. Neuron models III. Conductance-based and compartmental models. 6. Neuron models IV. Reduced models and phase space analysis. 7. Models of synapses. 8. Models of networks of neurons. Antonio Carlos Roque da Silva Filho 25 5915756 6 Lists of exercises (40% of final grade); Computer projects (60% of final grade). https://www.google.com.br/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiBp_-p9NzYAhWHkZAKHY_oACkQFggnMAA&url=http%3A%2F%2Fwww.ffclrp.usp.br%2Fdown.php%3Fid%3D1430%26d&usg=AOvVaw3-C7BSHGAhorxoB-Rfx8dD

Most graduate courses refer to theoretical or laboratory “contents” to be taught to students. Our proposal is not only to offer a general course on scientific methodology but to share with the students certain practical aspects of scientific work that are not found in textbooks and/or formal courses. From a constructivist perspective, we emphasize the importance of oral and written communication skills in all aspects of scientific career. To offer an updated view on scientific research, both in its methodological and theoretical aspects as in its daily practice. Faculty of Philosophy, Sciences and Letters at Ribeir?o Preto (FFCLRP) Ribeir?o Preto campus 1. What is science? Introduction to the history and philosophy of science. 2. Why the scientific method is not used by scientists? Feyrabend, Goldstein and knowledge ethics. 3. The first year in a graduate course. a. How to generate ideas: views from scientists of the past and the present. b. The choice of a research theme. The roles of the supervisor and the student. c. How to write a research project to the funding agencies. d. Efficient bibliographic searches. e. Efficient study techniques. 4. The intermediate years in a graduate course. a. Heuristic techniques commonly used in scientific research. b. What to do if your research project seems to be failing. c. How to elaborate the qualification exam work: what the examiners expect from you. d. How to write reports to funding agencies. 5. The last semester in a graduate course. a. How to write a masters dissertation or a doctorate thesis: norms, organization and style. b. How to prepare for the masters dissertation or doctorate thesis defense: what the examiners expect from you. 6. Promoting your research. a. How to promote your work: from preprint servers to scientific meetings. b. How to elaborate a good poster. c. How to give a good seminar. d. How to write well your scientific papers: formal and aesthetic criteria. e. How to submit papers to indexed journals. f. How to respond to reviewers who criticize your work and what to do if your paper is rejected. 7. Special topics on scientific publishing. a. Peer review: pros, cons and alternatives. b. Indexed journals. ISI Web of Science. Impact indices. c. Productivity indices. Brazilian science statistics. d. The science publishing market and the open access movement. 8. The researcher/professor professional career. a. CV preparation. b. Perspectives for a recently formed doctor: postdoctorate and special programs from funding agencies. c. The researcher/professor in universities and public schools. d. The researcher/professor in private universities. e. The researcher in research and technology innovation institutions. f. The researcher-entrepreneur. Antonio Carlos Roque da Silva Filho, Osame Kinouchi Filho 25 5915764 2 EVALUATION CRITERIA: Seminars given by students (S) and reports (R) on seminars given by invited speakers. Final grade: (S +?)/2 where?is the mean of the reports’ grades. https://www.google.com.br/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiBp_-p9NzYAhWHkZAKHY_oACkQFggnMAA&url=http%3A%2F%2Fwww.ffclrp.usp.br%2Fdown.php%3Fid%3D1430%26d&usg=AOvVaw3-C7BSHGAhorxoB-Rfx8dD